biostudies-literatureUnknown114Lin RJ<h4>Background</h4>First described in 1972, idiopathic subglottic stenosis (iSGS) is a serious chronic orphan disease characterised by recurrent scarring of the subglottis. Although the cause is unknown, iSGS is almost exclusively restricted to Caucasian females typically in their fourth to sixth decade. However, given its rare incidence (1:400,000), understanding the clinical trajectory and molecular factors associated with iSGS disease development and prognosis has been difficult. In the current study we sought to unravel the pathogenesis of iSGS at the clinical, transcriptional, and genetic level in a prospective cohort.<h4>Methods</h4>We prospectively enrolled 126 patients with iSGS, 104 controls, and 13 patients with traumatic SGS. Within this cohort, we profiled 114 human epiglottis EBioMedicine105629https://www.ebi.ac.uk/biostudies/studies/S-EPMC11924928biostudies-literatureCohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology-a study of the Canadian airways research (CARE) group.PMC11924928MacInnis PInculet RZeng PYWoo EFung KLin SYing SShaikh MHMymryk JSHu ALin RJCecchini MJZeng PYFAl Jawhri MJarycki LKhan HPan HAnderson JNichols ACCanadian Airways Research Group of the Canadian Society of Otolaryngology Collaborative Research InitiativeKarimi ABarrett JWCoburn BfalseCohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology-a study of the Canadian airways research (CARE) group.<h4>Background</h4>First described in 1972, idiopathic subglottic stenosis (iSGS) is a serious chronic orphan disease characterised by recurrent scarring of the subglottis. Although the cause is unknown, iSGS is almost exclusively restricted to Caucasian females typically in their fourth to sixth decade. However, given its rare incidence (1:400,000), understanding the clinical trajectory and molecular factors associated with iSGS disease development and prognosis has been difficult. In the current study we sought to unravel the pathogenesis of iSGS at the clinical, transcriptional, and genetic level in a prospective cohort.<h4>Methods</h4>We prospectively enrolled 126 patients with iSGS, 104 controls, and 13 patients with traumatic SGS. Within this cohort, we profiled 114 human epiglottis 2025-01-01T00:00:00Z2025 Mar2025-04-04T00:08:23.072Z2025-04-04T00:08:23.072ZS-EPMC119249284004884710.1016/j.ebiom.2025.105629