{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Thieulent CJ"],"pubmed_abstract":["Comorbidities, including obesity and type 2 diabetes mellitus (T2DM), are associated with increased disease severity and mortality following SARS-CoV-2 infection. Here, we investigated virus-host interactions under the effects of these comorbidities in diet-induced obesity (DIO) and leptin receptor-deficient (T2DM) mice following infection with SARS-CoV-2. DIO mice, as well as their lean counterparts, showed limited susceptibility to SARS-CoV-2 infection. In contrast, T2DM mice showed exacerbated pulmonary SARS-CoV-2 replication and delayed viral clearance associated with down-regulation of innate and adaptative immune gene signatures, ineffective type I interferon response, and delayed SARS-CoV-2-specific cell-mediated immune responses. While T2DM mice showed higher and prolonged SARS-CoV"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1513687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11925909"],"repository":["biostudies-literature"],"pubmed_title":["Diabetes exacerbates SARS-CoV-2 replication through ineffective pulmonary interferon responses, delayed cell-mediated immunity, and disruption of leptin signaling."],"pmcid":["PMC11925909"],"pubmed_authors":["Stephens JM","Richt JA","Carossino M","Staszkiewicz J","Thieulent CJ","Tseng A","Dittmar W","Balasuriya UBR","Crossland NA"],"additional_accession":[]},"is_claimable":false,"name":"Diabetes exacerbates SARS-CoV-2 replication through ineffective pulmonary interferon responses, delayed cell-mediated immunity, and disruption of leptin signaling.","description":"Comorbidities, including obesity and type 2 diabetes mellitus (T2DM), are associated with increased disease severity and mortality following SARS-CoV-2 infection. Here, we investigated virus-host interactions under the effects of these comorbidities in diet-induced obesity (DIO) and leptin receptor-deficient (T2DM) mice following infection with SARS-CoV-2. DIO mice, as well as their lean counterparts, showed limited susceptibility to SARS-CoV-2 infection. In contrast, T2DM mice showed exacerbated pulmonary SARS-CoV-2 replication and delayed viral clearance associated with down-regulation of innate and adaptative immune gene signatures, ineffective type I interferon response, and delayed SARS-CoV-2-specific cell-mediated immune responses. While T2DM mice showed higher and prolonged SARS-CoV","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-02T17:27:07.388Z","creation":"2025-04-05T22:08:35.996Z"},"accession":"S-EPMC11925909","cross_references":{"pubmed":["40125513"],"doi":["10.3389/fcimb.2025.1513687"]}}