{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["201(4)"],"submitter":["Paterson LC"],"funding":["Atomic Energy of Canada Limited's Federal Nuclear Science & Technology Work Plan"],"pubmed_abstract":["The reported relative biological effectiveness (RBE) for thermal neutrons has a large range (5-51, for cytogenetic endpoints), which can confound radiation protection decision-making. To determine whether thermal neutron spectra can influence RBE, the RBE of reactor-derived thermal neutrons of average energy 31 meV was evaluated in human peripheral blood lymphocytes using two classical DNA double-strand break endpoints: the dicentric chromosome assay (DCA) and the cytokinesis-block micronucleus assay. Dose-response curves for 41 to 408 mGy revealed a preference for linear regression. Maximum RBE (RBEM) values of 6.7 ± 0.9 and 4.4 ± 0.7 were calculated for the DCA and the micronucleus assay, respectively. These 31 meV RBEM values were significantly lower than our prior results for 64 meV th"],"journal":["Radiation protection dosimetry"],"pagination":["297-313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11926985"],"repository":["biostudies-literature"],"pubmed_title":["Relative biological effectiveness of 31 meV thermal neutrons in peripheral blood lymphocytes."],"pmcid":["PMC11926985"],"pubmed_authors":["Boyer C","Paterson LC","Ali F","Naseri M","Costello C","Perez Loureiro D","Ybarra N","Stuart M","Festarini A","Rogge R","Kildea J","Richardson RB"],"additional_accession":[]},"is_claimable":false,"name":"Relative biological effectiveness of 31 meV thermal neutrons in peripheral blood lymphocytes.","description":"The reported relative biological effectiveness (RBE) for thermal neutrons has a large range (5-51, for cytogenetic endpoints), which can confound radiation protection decision-making. To determine whether thermal neutron spectra can influence RBE, the RBE of reactor-derived thermal neutrons of average energy 31 meV was evaluated in human peripheral blood lymphocytes using two classical DNA double-strand break endpoints: the dicentric chromosome assay (DCA) and the cytokinesis-block micronucleus assay. Dose-response curves for 41 to 408 mGy revealed a preference for linear regression. Maximum RBE (RBEM) values of 6.7 ± 0.9 and 4.4 ± 0.7 were calculated for the DCA and the micronucleus assay, respectively. These 31 meV RBEM values were significantly lower than our prior results for 64 meV th","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-05T12:38:43.397Z","creation":"2025-04-05T12:38:43.397Z"},"accession":"S-EPMC11926985","cross_references":{"pubmed":["40062825"],"doi":["10.1093/rpd/ncae231"]}}