biostudies-literatureUnknown30(11)Martins Simoes PBackground<i>Staphylococcus haemolyticus</i> (SH) is an opportunistic pathogen associated with nosocomial infections, particularly bacteraemia in neonates. Epidemiological trends and genetic diversity of these infections worldwide are largely unknown.AimTo investigate an increase in SH vascular catheter-related bacteraemia in neonates and describe the molecular epidemiology in France between 2019 and 2023.MethodsWe analysed clinical and microbiological surveillance data from the French national surveillance network for central catheter-related (venous and umbilical) infections between 2019 and 2023. We also performed genomic and phylogenetic analyses of 496 strains isolated both inside (n = 383 from neonates, staff and environmental samples) and outside (n = 113 from adults) the neonatal iEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletinhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC11927072biostudies-literatureEpidemiology of <i>Staphylococcus haemolyticus</i> nosocomial bacteraemia in neonatal intensive care units, France, 2019 to 2023: predominance of the ST29 (CC3) multidrug-resistant lineage.PMC11927072Ranc AGVernet-Garnier VFascia PRomano-Bertrand SLeyssene DVerhoeven PCanouet SBarreto CBenet CLamoureux CMenard CLecuyer HMenard GDonnio PYKolenda CVandenesch FDubois DBailly PCavalie LIdri NVacher SBourgeois-Nicolaos NYouenou BLaurent FGrattard FPailhories HDeroin VFais TLiberge MBeauruelle CBoileau PLedru SLemarie CDumont Yvan der Mee-Marquet NTristan AMotte-Signoret EDupin CStordeur FMaurin EMartins Simoes PChagneau CGibert LGrisi BS. haemolyticus neonatal infections Study GroupBertrand XCisse ALefflot SSauget MLawrence CLe Glass EMuggeo ALabbe FMourlan CButin MDupieux-Chabert CBerger-Carbonne AGaudichon AMezard ICheron MLe Bars HPlainvert CMiquel CLecorche ELehours PLaurens EBernard ETazi ALafeuille ELe Bouedec SfalseEpidemiology of <i>Staphylococcus haemolyticus</i> nosocomial bacteraemia in neonatal intensive care units, France, 2019 to 2023: predominance of the ST29 (CC3) multidrug-resistant lineage.Background<i>Staphylococcus haemolyticus</i> (SH) is an opportunistic pathogen associated with nosocomial infections, particularly bacteraemia in neonates. Epidemiological trends and genetic diversity of these infections worldwide are largely unknown.AimTo investigate an increase in SH vascular catheter-related bacteraemia in neonates and describe the molecular epidemiology in France between 2019 and 2023.MethodsWe analysed clinical and microbiological surveillance data from the French national surveillance network for central catheter-related (venous and umbilical) infections between 2019 and 2023. We also performed genomic and phylogenetic analyses of 496 strains isolated both inside (n = 383 from neonates, staff and environmental samples) and outside (n = 113 from adults) the neonatal i2025-01-01T00:00:00Z2025 Mar2026-06-01T06:04:43.683Z2026-04-08T09:44:16.054ZS-EPMC119270724011603110.2807/1560-7917.ES.2025.30.11.2400309