{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(3)"],"submitter":["Riffe RM"],"funding":["University of Massachusetts Amherst"],"pubmed_abstract":["The five-subunit endosomal Rab5 and RNA/ribose intermediary (FERRY) complex is a newly described protein complex consisting of TBCK, PPP1R21, FERRY3 (previously C12orf4), CRYZL1, and GATD1. The FERRY complex is proposed to function as a Rab5 effector to shuttle mRNA to the cell periphery for local translation, a process especially important in cells with far reaching processes. Interestingly, three members of the FERRY complex are associated with ultra-rare neurogenetic disorders. Mutation of TBCK causes TBCK syndrome, mutation of PPP1R21 is associated with PPP1R21-related intellectual disability, and mutation of FERRY3 results in an autosomal recessive intellectual disability. Neurologic disorders have yet to be associated with mutation of GATD1 or CRYZL1. Here, we provide a review of eac"],"journal":["Biology open"],"pagination":["BIO061808"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11928052"],"repository":["biostudies-literature"],"pubmed_title":["Neurogenetic disorders associated with mutations in the FERRY complex: a novel disease class?"],"pmcid":["PMC11928052"],"pubmed_authors":["Riffe RM","Downes GB"],"additional_accession":[]},"is_claimable":false,"name":"Neurogenetic disorders associated with mutations in the FERRY complex: a novel disease class?","description":"The five-subunit endosomal Rab5 and RNA/ribose intermediary (FERRY) complex is a newly described protein complex consisting of TBCK, PPP1R21, FERRY3 (previously C12orf4), CRYZL1, and GATD1. The FERRY complex is proposed to function as a Rab5 effector to shuttle mRNA to the cell periphery for local translation, a process especially important in cells with far reaching processes. Interestingly, three members of the FERRY complex are associated with ultra-rare neurogenetic disorders. Mutation of TBCK causes TBCK syndrome, mutation of PPP1R21 is associated with PPP1R21-related intellectual disability, and mutation of FERRY3 results in an autosomal recessive intellectual disability. Neurologic disorders have yet to be associated with mutation of GATD1 or CRYZL1. Here, we provide a review of eac","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-08T19:51:35.838Z","creation":"2026-04-08T14:31:02.086Z"},"accession":"S-EPMC11928052","cross_references":{"pubmed":["40062705"],"doi":["10.1242/bio.061808"]}}