{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin Q"],"funding":["Fundamental Research Funds for the Central Universities","Basic and Applied Basic Research Fund of Guangzhou","Construction project of Guangdong Famous Traditional Chinese Medicine Inheritance Studio of Ronghua Zhang","National Natural Science Foundation of China","Guangdong Provincial Key laboratory of Traditional Chinese Medicine Informatization","National Key Research and Development Program of China"],"pagination":["127-141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11928296"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(3)"],"pubmed_abstract":["Drynariae Rhizoma has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of Drynariae Rhizoma in a bilateral ovariectomized rat model and explore the correlation with gut microbiome. We established an ovariectomized rat model, which we treated with different doses of Drynariae Rhizoma (Drynariae Rhizoma-Low, 0.27 g/kg/day; Drynariae Rhizoma-Middle, 0.81 g/kg/day; Drynariae Rhizoma-High, 2.43 g/kg/day) through intragastric administration for 12 weeks. Results showed that Drynariae Rhizoma alleviated body weight, moderated bone microstructure, and promoted the expression of bone formation-related factors in ovariectomized rats, in which Drynariae Rhizoma-"],"journal":["Planta medica"],"pubmed_title":["Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota."],"pmcid":["PMC11928296"],"funding_grant_id":["82274232, 82274376, and 82074287","2018YFC2002500","21622329, 21623115, 21624225","SL2022A04J00516","Guangdong Traditional Chinese Medicine Letter","2022B1515120022"],"pubmed_authors":["Li X","Lin Q","Yang Y","Yang L","Ouyang X","Huang J","Zhang Z","Zhu X","Pan Q","Wang H","Zhang R"],"additional_accession":[]},"is_claimable":false,"name":"Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota.","description":"Drynariae Rhizoma has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of Drynariae Rhizoma in a bilateral ovariectomized rat model and explore the correlation with gut microbiome. We established an ovariectomized rat model, which we treated with different doses of Drynariae Rhizoma (Drynariae Rhizoma-Low, 0.27 g/kg/day; Drynariae Rhizoma-Middle, 0.81 g/kg/day; Drynariae Rhizoma-High, 2.43 g/kg/day) through intragastric administration for 12 weeks. Results showed that Drynariae Rhizoma alleviated body weight, moderated bone microstructure, and promoted the expression of bone formation-related factors in ovariectomized rats, in which Drynariae Rhizoma-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-04T03:05:58.638Z","creation":"2025-07-04T03:05:58.638Z"},"accession":"S-EPMC11928296","cross_references":{"pubmed":["39500341"],"doi":["10.1055/a-2462-4844"]}}