biostudies-literatureLin QFundamental Research Funds for the Central UniversitiesBasic and Applied Basic Research Fund of GuangzhouConstruction project of Guangdong Famous Traditional Chinese Medicine Inheritance Studio of Ronghua ZhangNational Natural Science Foundation of ChinaGuangdong Provincial Key laboratory of Traditional Chinese Medicine InformatizationNational Key Research and Development Program of China127-141https://www.ebi.ac.uk/biostudies/studies/S-EPMC11928296biostudies-literatureUnknown91(3)Drynariae Rhizoma has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of Drynariae Rhizoma in a bilateral ovariectomized rat model and explore the correlation with gut microbiome. We established an ovariectomized rat model, which we treated with different doses of Drynariae Rhizoma (Drynariae Rhizoma-Low, 0.27 g/kg/day; Drynariae Rhizoma-Middle, 0.81 g/kg/day; Drynariae Rhizoma-High, 2.43 g/kg/day) through intragastric administration for 12 weeks. Results showed that Drynariae Rhizoma alleviated body weight, moderated bone microstructure, and promoted the expression of bone formation-related factors in ovariectomized rats, in which Drynariae Rhizoma-Planta medicaExtracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota.PMC1192829682274232, 82274376, and 820742872018YFC200250021622329, 21623115, 21624225SL2022A04J00516Guangdong Traditional Chinese Medicine Letter2022B1515120022Li XLin QYang YYang LOuyang XHuang JZhang ZZhu XPan QWang HZhang RfalseExtracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota.Drynariae Rhizoma has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of Drynariae Rhizoma in a bilateral ovariectomized rat model and explore the correlation with gut microbiome. We established an ovariectomized rat model, which we treated with different doses of Drynariae Rhizoma (Drynariae Rhizoma-Low, 0.27 g/kg/day; Drynariae Rhizoma-Middle, 0.81 g/kg/day; Drynariae Rhizoma-High, 2.43 g/kg/day) through intragastric administration for 12 weeks. Results showed that Drynariae Rhizoma alleviated body weight, moderated bone microstructure, and promoted the expression of bone formation-related factors in ovariectomized rats, in which Drynariae Rhizoma-2025-01-01T00:00:00Z2025 Mar2025-07-04T03:05:58.638Z2025-07-04T03:05:58.638ZS-EPMC119282963950034110.1055/a-2462-4844