{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Topolska JM"],"funding":["\"Excellence Initiative - Research University\" for AGH University of Krakow, (previously named as AGH University of Science and Technology)","AGH Statutory Funding","National Science Centre of Poland",""Excellence Initiative - Research University" for AGH University of Krakow,"],"pagination":["9825"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11928628"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["The presence of trace metals in the oral cavity, whether natural or treatment-induced, may influence enamel properties and health. Evidence suggests that metals released from orthodontic appliances affect enamel integrity, though the underlying mechanisms remain unclear. This study examined whether Fe ions from orthodontic devices preferentially incorporate into either the buccal or lingual enamel. For this, six human molars underwent a 12-month in vitro simulation involving metal appliances and cyclic pH fluctuations. Bacterial and enzymatic effects were not assessed. Lingual-buccal enamel cross-sections were analysed using LA-ICP-MS pre- and post-experiment. Fe concentration increased over time, varying among teeth. Fe accumulated significantly more (Student's t-test, p = 0.000000) and p"],"journal":["Scientific reports"],"pubmed_title":["Fe leaking from orthodontic appliances affects buccal enamel more than lingual during in vitro experiment."],"pmcid":["PMC11928628"],"funding_grant_id":["16.16.140.315.","2016/21/D/ST10/00738","5180"],"pubmed_authors":["Jagielska A","Kozub-Budzyn GA","Wagner B","Topolska JM","Motyl S"],"additional_accession":[]},"is_claimable":false,"name":"Fe leaking from orthodontic appliances affects buccal enamel more than lingual during in vitro experiment.","description":"The presence of trace metals in the oral cavity, whether natural or treatment-induced, may influence enamel properties and health. Evidence suggests that metals released from orthodontic appliances affect enamel integrity, though the underlying mechanisms remain unclear. This study examined whether Fe ions from orthodontic devices preferentially incorporate into either the buccal or lingual enamel. For this, six human molars underwent a 12-month in vitro simulation involving metal appliances and cyclic pH fluctuations. Bacterial and enzymatic effects were not assessed. Lingual-buccal enamel cross-sections were analysed using LA-ICP-MS pre- and post-experiment. Fe concentration increased over time, varying among teeth. Fe accumulated significantly more (Student's t-test, p = 0.000000) and p","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-04T07:51:53.274Z","creation":"2026-06-01T03:07:04.323Z"},"accession":"S-EPMC11928628","cross_references":{"pubmed":["40119059"],"doi":["10.1038/s41598-025-94226-4"]}}