{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zang Y"],"funding":["Naito Foundation","Takeda Science Foundation","Japan Agency for Medical Research and Development","Ministry of Education, Culture, Sports, Science and Technology","Japan Society for the Promotion of Science"],"pagination":["112048"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11928871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(3)"],"pubmed_abstract":["Cellular senescence is an irreversible cell-cycle arrest often associated with cancer and aging, yet its physiological role remains elusive. Here, we show developmentally programmed cellular senescence occurs in <i>Drosophila</i> imaginal epithelium. In developing wing discs, two clusters of cells exhibit hallmarks of cellular senescence such as elevated senescence-associated β-galactosidase activity, cell-cycle arrest, heterochromatinization, upregulation of a cyclin-dependent kinase (CDK) inhibitor Dacapo, cellular hypertrophy, Ras signaling activation, and upregulation of an inflammatory cytokine unpaired3, a possible component of the senescence-associated secretory phenotype. Blocking programmed cell senescence by inhibiting Ras signaling or its downstream transcription factor Pointed "],"journal":["iScience"],"pubmed_title":["Programmed cell senescence is required for sensory organ development in &lt;i&gt;Drosophila&lt;/i&gt;."],"pmcid":["PMC11928871"],"funding_grant_id":["17938731","16K14606"],"pubmed_authors":["Igaki T","Zang Y","Yoshimoto M"],"additional_accession":[]},"is_claimable":false,"name":"Programmed cell senescence is required for sensory organ development in &lt;i&gt;Drosophila&lt;/i&gt;.","description":"Cellular senescence is an irreversible cell-cycle arrest often associated with cancer and aging, yet its physiological role remains elusive. Here, we show developmentally programmed cellular senescence occurs in <i>Drosophila</i> imaginal epithelium. In developing wing discs, two clusters of cells exhibit hallmarks of cellular senescence such as elevated senescence-associated β-galactosidase activity, cell-cycle arrest, heterochromatinization, upregulation of a cyclin-dependent kinase (CDK) inhibitor Dacapo, cellular hypertrophy, Ras signaling activation, and upregulation of an inflammatory cytokine unpaired3, a possible component of the senescence-associated secretory phenotype. Blocking programmed cell senescence by inhibiting Ras signaling or its downstream transcription factor Pointed ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-05-29T14:50:20.138Z","creation":"2026-04-08T05:06:40.227Z"},"accession":"S-EPMC11928871","cross_references":{"pubmed":["40124515"],"doi":["10.1016/j.isci.2025.112048"]}}