biostudies-literatureLyall KNHLBI NIH HHSNational Institutes of HealthNIH HHS648-659https://www.ebi.ac.uk/biostudies/studies/S-EPMC11929602biostudies-literatureUnknown18(3)Prevalence of autism diagnosis has historically differed by demographic factors. Using data from 8224 participants drawn from the Environmental influences on Child Health Outcomes (ECHO) Program, we examined relationships between demographic factors and parent-reported autism-related traits as captured by the Social Responsiveness Scale (SRS; T score > 65) and compared these to relations with parent-reported clinician diagnosis of ASD, in generalized linear mixed effects regression analyses. Results suggested lower odds of autism diagnosis, but not of SRS T > 65, for non-Hispanic Black children (adjusted odds ratio [OR] = 0.76, 95% CI 0.55, 1.06) relative to non-Hispanic White children. Higher maternal education was associated with reduced odds of both outcomes (OR = 0.73, 95% CI 0.51, 1.0Autism research : official journal of the International Society for Autism ResearchDemographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure?PMC11929602R01 HL159701U24 OD023319UH3 OD023290UH3 OD023251UH3 OD023272UH3 OD023271UH3 OD023332UH3 OD023253UH3 OD023275UH3 OD023337UH3 OD023313UH3 OD023279U2C OD023375UH3 OD023318U24 OD023382UH3 OD023285UH3 OD023282UH3 OD023289UH3 OD023288UH3 OD023244UH3 OD023365UH3 OD023320UH3 OD023342UH3 OD023286UH3 OD023249UH3 OD023348UH3 OD023347UH3 OD023248UH3 OD023389UH3 OD023268K01 HL146980UH3 OD023328UH3 OD023349UH3 OD023305Kelly RSCatellier DJFrndak SKoinis-Mitchell DTrevino COSmith PBAmes JLDager SRGreen AMSchmidt RJLyall KAschner JLMcEvoy CTPage GPGaniban JMMargolis ACroen LAStanford JBOzonoff SCella DHertz-Picciotto IMiller MSheinkopf SJJoseph RMMa TGern JED'Sa VGissandaner TDMurphy LWeiss STHipwell AEGershon RSchweitzer JBBush NRFerrara ACamargo CADickerson ASVolk HESchantz SLDunlop ALNguyen RJacobson LPOken EGraff JCAvalos LAKaragas MRShuster CLNewby LKprogram collaborators for Environmental influences on Child Health OutcomesMessinger DfalseDemographic Correlates of Autism: How Do Associations Compare Between Diagnosis and a Quantitative Trait Measure?Prevalence of autism diagnosis has historically differed by demographic factors. Using data from 8224 participants drawn from the Environmental influences on Child Health Outcomes (ECHO) Program, we examined relationships between demographic factors and parent-reported autism-related traits as captured by the Social Responsiveness Scale (SRS; T score > 65) and compared these to relations with parent-reported clinician diagnosis of ASD, in generalized linear mixed effects regression analyses. Results suggested lower odds of autism diagnosis, but not of SRS T > 65, for non-Hispanic Black children (adjusted odds ratio [OR] = 0.76, 95% CI 0.55, 1.06) relative to non-Hispanic White children. Higher maternal education was associated with reduced odds of both outcomes (OR = 0.73, 95% CI 0.51, 1.02025-01-01T00:00:00Z2025 Mar2026-07-16T23:25:48.81Z2026-07-12T03:11:23.76ZS-EPMC119296023977806010.1002/aur.3296