biostudies-literatureUnknown16(1)Kokawa T<h4>Objectives</h4>Myocardial computed tomography late enhancement (CT-LE) is a valuable modality used for the assessment of myocardial infarction and fibrosis and is effective in detecting latent cardiac amyloidosis. However, the optimal acquisition mode for CT-LE remains unknown. Here, we compared single-energy shuttle mode and DE mode for improving the quality of CT-LE imaging using dual-source CT.<h4>Methods</h4>Fifteen patients with suspected or known ischemic heart disease underwent CT-LE imaging 5 min after coronary CT in both shuttle and dual-energy (DE) modes. In DE mode, virtual monoenergetic images at various keVs were reconstructed, and extracellular volume (ECV) was quantified using iodine-specific images. For shuttle mode, ECV was assessed by subtracting the volume from pre-cInsights into imaging64https://www.ebi.ac.uk/biostudies/studies/S-EPMC11929652biostudies-literatureMyocardial late enhancement using dual-source CT: intraindividual comparison of single-energy shuttle and dual-energy acquisition.PMC11929652Kitagawa KKokawa TOya TTakafuji MSakuma HNakamura SfalseMyocardial late enhancement using dual-source CT: intraindividual comparison of single-energy shuttle and dual-energy acquisition.<h4>Objectives</h4>Myocardial computed tomography late enhancement (CT-LE) is a valuable modality used for the assessment of myocardial infarction and fibrosis and is effective in detecting latent cardiac amyloidosis. However, the optimal acquisition mode for CT-LE remains unknown. Here, we compared single-energy shuttle mode and DE mode for improving the quality of CT-LE imaging using dual-source CT.<h4>Methods</h4>Fifteen patients with suspected or known ischemic heart disease underwent CT-LE imaging 5 min after coronary CT in both shuttle and dual-energy (DE) modes. In DE mode, virtual monoenergetic images at various keVs were reconstructed, and extracellular volume (ECV) was quantified using iodine-specific images. For shuttle mode, ECV was assessed by subtracting the volume from pre-c2025-01-01T00:00:00Z2025 Mar2025-07-09T03:04:33.624Z2025-07-09T03:04:33.624ZS-EPMC119296524012000710.1186/s13244-025-01944-4