{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Kapcan E"],"pubmed_abstract":["A special class of proximity inducing bifunctional molecules/chimeras called molecular glues leverage positive co-operativity to stabilize ternary complex formation and induce a biological response. Despite their utility, molecular glues remain challenging to rationally design. This is particularly true in the context of inducing cell-cell proximity which involve ternary complexes that comprise non- or negatively interacting proteins. In this work, we develop a dual proximity labeling strategy enabling a chimera to covalently crosslink a non-interacting serum antibody to a tumor surface protein, within a ternary complex. The resultant resistance to dissociation, including in the presence of competitor binding ligands, mimics molecular glue stabilization. We demonstrate these covalent glue "],"journal":["Nature communications"],"pagination":["2855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11933337"],"repository":["biostudies-literature"],"pubmed_title":["Mimicry of molecular glues using dual covalent chimeras."],"pmcid":["PMC11933337"],"pubmed_authors":["Rullo AF","Krygier K","da Luz M","Serniuck NJ","Zhang A","Kapcan E","Bramson J"],"additional_accession":[]},"is_claimable":false,"name":"Mimicry of molecular glues using dual covalent chimeras.","description":"A special class of proximity inducing bifunctional molecules/chimeras called molecular glues leverage positive co-operativity to stabilize ternary complex formation and induce a biological response. Despite their utility, molecular glues remain challenging to rationally design. This is particularly true in the context of inducing cell-cell proximity which involve ternary complexes that comprise non- or negatively interacting proteins. In this work, we develop a dual proximity labeling strategy enabling a chimera to covalently crosslink a non-interacting serum antibody to a tumor surface protein, within a ternary complex. The resultant resistance to dissociation, including in the presence of competitor binding ligands, mimics molecular glue stabilization. We demonstrate these covalent glue ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-01T06:10:05.231Z","creation":"2026-04-08T09:46:56.563Z"},"accession":"S-EPMC11933337","cross_references":{"pubmed":["40128528"],"doi":["10.1038/s41467-025-58083-z"]}}