{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4"],"submitter":["Kronenberg PA"],"pubmed_abstract":["Alveolar echinococcosis (AE) caused by <i>Echinococcus multilocularis</i>, is a severe zoonotic disease in humans. One of the major metacestode antigens of <i>E. multilocularis</i> is the Em2 or Em2(G11) native purified antigen. The Em2 antigen is used for the serological and histopathological diagnosis of AE in humans and plays an important role in parasite-host interactions. As the Em2(G11) antigen is a mucin-type and glycosylated protein, the protein backbone has not been identified yet. We have targeted the protein backbone identification through mass spectrometry (LC-MS/MS) analysis of the Em2(G11) antigen. As a result, we evidenced that the Em2(G11) antigen consists of 33 unique protein candidates of which the most abundant was ''EmuJ_001105600.1''. This protein (889 amino acids) had"],"journal":["Frontiers in parasitology"],"pagination":["1540215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11935348"],"repository":["biostudies-literature"],"pubmed_title":["Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of &lt;i&gt;Echinococcus multilocularis&lt;/i&gt;."],"pmcid":["PMC11935348"],"pubmed_authors":["Reinehr M","Kronenberg PA","Deibel A","Eichenberger RM","Deplazes P","Laurimae T","Hasler S","Gehrig P","Weber A"],"additional_accession":[]},"is_claimable":false,"name":"Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of &lt;i&gt;Echinococcus multilocularis&lt;/i&gt;.","description":"Alveolar echinococcosis (AE) caused by <i>Echinococcus multilocularis</i>, is a severe zoonotic disease in humans. One of the major metacestode antigens of <i>E. multilocularis</i> is the Em2 or Em2(G11) native purified antigen. The Em2 antigen is used for the serological and histopathological diagnosis of AE in humans and plays an important role in parasite-host interactions. As the Em2(G11) antigen is a mucin-type and glycosylated protein, the protein backbone has not been identified yet. We have targeted the protein backbone identification through mass spectrometry (LC-MS/MS) analysis of the Em2(G11) antigen. As a result, we evidenced that the Em2(G11) antigen consists of 33 unique protein candidates of which the most abundant was ''EmuJ_001105600.1''. This protein (889 amino acids) had","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T05:39:46.003Z","creation":"2025-07-02T03:04:36.967Z"},"accession":"S-EPMC11935348","cross_references":{"pubmed":["40135073"],"doi":["10.3389/fpara.2025.1540215"]}}