biostudies-literatureUnknown3Kelley GA<h4>Background</h4>Determine whether true exercise-associated interindividual response differences (IIRD) occur in cardiorespiratory fitness as a result of exercise-based cardiac rehabilitation in heart transplant patients.<h4>Methods</h4>Using data from a recent (2023) meta-analysis of 9 randomized controlled trials representing 296 patients (163 exercise, 133 control), an aggregate data meta-analysis of treatment effects (change outcome differences between exercise and control groups) was conducted as well as an IIRD meta-analysis using the inverse variance heterogeneity model. The primary outcome was cardiorespiratory fitness (VO_2max) in ml/kg/min.<h4>Results</h4>Statistically significant and clinically important increases equivalent to 14.5% were observed for VO_2max in ml/kg/min ( X® , 3.0, 95% confidence interval (CI), 2.4-3.7 ml/kg/min, <i>p</i> < 0.001; Q = 11.8, <i>p</i> = 0.16; <i>I</i> ² = 32.0%, 95% CI, 0%-68.8%; τ2  = 0.4). The 95% prediction interval (PI) was 1.2-4.7 ml/kg/min. However, no statistically significant IIRD were observed ( X® , 0.6, 95% CI, -1.1 to 1.4 ml/kg/min; τ2  = 2.9). The 95% PI was -2.7 to 2.8 ml/kg/min.<h4>Conclusions</h4>While exercise-based cardiac rehabilitation increases VO_2max in ml/kg/min in heart transplant patients, a lack of true exercise-associated IIRD exists. A need exists for additional well-designed randomized controlled trials of longer duration to determine the long-term effects of exercise-based cardiac rehabilitation on VO_2max in ml/kg/min heart transplant patients.JHLT open100033https://www.ebi.ac.uk/biostudies/studies/S-EPMC11935367biostudies-literatureInterindividual response variation to exercise-based cardiac rehabilitation on changes in cardiorespiratory fitness in heart transplant patients: A secondary meta-analysis of randomized controlled trials.PMC11935367Kelley GAStauffer BLKelley KSfalseInterindividual response variation to exercise-based cardiac rehabilitation on changes in cardiorespiratory fitness in heart transplant patients: A secondary meta-analysis of randomized controlled trials.<h4>Background</h4>Determine whether true exercise-associated interindividual response differences (IIRD) occur in cardiorespiratory fitness as a result of exercise-based cardiac rehabilitation in heart transplant patients.<h4>Methods</h4>Using data from a recent (2023) meta-analysis of 9 randomized controlled trials representing 296 patients (163 exercise, 133 control), an aggregate data meta-analysis of treatment effects (change outcome differences between exercise and control groups) was conducted as well as an IIRD meta-analysis using the inverse variance heterogeneity model. The primary outcome was cardiorespiratory fitness (VO_2max) in ml/kg/min.<h4>Results</h4>Statistically significant and clinically important increases equivalent to 14.5% were observed for VO_2max in ml/kg/min ( X® , 3.0, 95% confidence interval (CI), 2.4-3.7 ml/kg/min, <i>p</i> < 0.001; Q = 11.8, <i>p</i> = 0.16; <i>I</i> ² = 32.0%, 95% CI, 0%-68.8%; τ2  = 0.4). The 95% prediction interval (PI) was 1.2-4.7 ml/kg/min. However, no statistically significant IIRD were observed ( X® , 0.6, 95% CI, -1.1 to 1.4 ml/kg/min; τ2  = 2.9). The 95% PI was -2.7 to 2.8 ml/kg/min.<h4>Conclusions</h4>While exercise-based cardiac rehabilitation increases VO_2max in ml/kg/min in heart transplant patients, a lack of true exercise-associated IIRD exists. A need exists for additional well-designed randomized controlled trials of longer duration to determine the long-term effects of exercise-based cardiac rehabilitation on VO_2max in ml/kg/min heart transplant patients.2024-01-01T00:00:00Z2024 Feb2025-07-02T03:04:39.431Z2025-07-02T03:04:39.431ZS-EPMC119353674014511510.1016/j.jhlto.2023.100033