{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Eichenwald LS"],"pubmed_abstract":["<h4>Background</h4>Patients with advanced heart failure needing heart transplant commonly suffer liver dysfunction. However, there is limited data on the impact of liver fibrosis on outcomes for heart transplant (HT) candidates. We determine the relationship between liver fibrosis severity and mortality rates for HT patients.<h4>Methods</h4>A retrospective cohort study of adults listed for HT who underwent a liver biopsy for evaluation of early or advanced liver fibrosis from August 12, 2004 to February 16, 2022. Trend analysis was performed using Cox proportional hazard model, controlling for MELD-XI. At-risk period starts at the time of waitlist; the end of the follow-up period was mortality on the waitlist, mortality post-HT, or administrative censoring at the end of the study.<h4>Resul"],"journal":["JHLT open"],"pagination":["100187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11935397"],"repository":["biostudies-literature"],"pubmed_title":["Association of liver biopsy pathology on outcome of patients undergoing heart transplantation."],"pmcid":["PMC11935397"],"pubmed_authors":["Eichenwald LS","Stein A","Eichenwald AJ","Morrissey J","Kini S","Vest AR","Karagozian R"],"additional_accession":[]},"is_claimable":false,"name":"Association of liver biopsy pathology on outcome of patients undergoing heart transplantation.","description":"<h4>Background</h4>Patients with advanced heart failure needing heart transplant commonly suffer liver dysfunction. However, there is limited data on the impact of liver fibrosis on outcomes for heart transplant (HT) candidates. We determine the relationship between liver fibrosis severity and mortality rates for HT patients.<h4>Methods</h4>A retrospective cohort study of adults listed for HT who underwent a liver biopsy for evaluation of early or advanced liver fibrosis from August 12, 2004 to February 16, 2022. Trend analysis was performed using Cox proportional hazard model, controlling for MELD-XI. At-risk period starts at the time of waitlist; the end of the follow-up period was mortality on the waitlist, mortality post-HT, or administrative censoring at the end of the study.<h4>Resul","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-07-02T03:04:43.889Z","creation":"2025-07-02T03:04:43.889Z"},"accession":"S-EPMC11935397","cross_references":{"pubmed":["40144842"],"doi":["10.1016/j.jhlto.2024.100187"]}}