{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Hu D"],"funding":["Okinawa Institute of Science and Technology Graduate University"],"pubmed_abstract":["Cone photoreceptors assemble to form a regular mosaic pattern in vertebrate retinas. In zebrafish, four distinct spectral cone types (red, green, blue, and ultraviolet), form a lattice-like pattern. However, the mechanism of cone mosaic formation has been unknown. Here we show that Down Syndrome Cell Adhesion Molecule b (Dscamb) regulates the cone mosaic pattern in zebrafish, especially via red-cone spacing. During photoreceptor differentiation, newly formed cones extend filopodium-like processes laterally to apical surfaces of neighboring cones. Interestingly, red cones extend filopodia, but promptly retract them when they meet their own cone type, suggesting filopodium-mediated, homotypic recognition and self-avoidance. This self-avoidance is compromised in zebrafish dscamb mutants, lead"],"journal":["Nature communications"],"pagination":["2501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11937385"],"repository":["biostudies-literature"],"pubmed_title":["Dscamb regulates cone mosaic formation in zebrafish via filopodium-mediated homotypic recognition."],"pmcid":["PMC11937385"],"pubmed_authors":["Hu D","Masai I"],"additional_accession":[]},"is_claimable":false,"name":"Dscamb regulates cone mosaic formation in zebrafish via filopodium-mediated homotypic recognition.","description":"Cone photoreceptors assemble to form a regular mosaic pattern in vertebrate retinas. In zebrafish, four distinct spectral cone types (red, green, blue, and ultraviolet), form a lattice-like pattern. However, the mechanism of cone mosaic formation has been unknown. Here we show that Down Syndrome Cell Adhesion Molecule b (Dscamb) regulates the cone mosaic pattern in zebrafish, especially via red-cone spacing. During photoreceptor differentiation, newly formed cones extend filopodium-like processes laterally to apical surfaces of neighboring cones. Interestingly, red cones extend filopodia, but promptly retract them when they meet their own cone type, suggesting filopodium-mediated, homotypic recognition and self-avoidance. This self-avoidance is compromised in zebrafish dscamb mutants, lead","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-15T14:39:33.056Z","creation":"2026-07-07T03:08:26.964Z"},"accession":"S-EPMC11937385","cross_references":{"pubmed":["40133281"],"doi":["10.1038/s41467-025-57506-1"]}}