{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nab L"],"funding":["Trombosestichting Nederland","ZonMw","the Dutch Heart Foundation","Netherlands Organization for Health Research and Development"],"pagination":["10321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11937556"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on the optimal dosage of thromboprophylaxis in critically ill COVID-19 patients. We utilized data from the multicentre CAPACITY-COVID patient registry to assess the effect of differential application of Low Molecular Weight Heparin (LMWH) dose protocols on PE and in-hospital mortality risk in critically ill COVID-19 patients. An instrumental variable analysis was performed to estimate the intention-to-treat effect, utilizing differences in thromboprophylaxis prescribing behaviour between hospitals. We included 939 patients with PCR confirmed SARS-CoV-2 infection from 34 hospitals. Two-hundred-and-one "],"journal":["Scientific reports"],"pubmed_title":["Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis."],"pmcid":["PMC11937556"],"funding_grant_id":["2020_A","10430012010004","project number 10430012010004","2020B006 CAPACITY"],"pubmed_authors":["Kusadasi N","de Jonge E","Hackeng TM","Asselbergs FW","Ten Cate-Hoek AJ","Schellings DAAM","Williams B","Koopmans MPG","Hedayat B","Rokx C","Westendorp PHM","Alshehri AM","Almubarak YA","Douma RA","Martens FMAC","Al-Ali AK","Stemerdink A","van de Watering DJ","van de Beek D","Leebeek FWG","Noack D","Nierop PR","Rockx B","Hulshof AM","de Vries JK","Hermanides RS","Veneman T","van den Akker J","Winckers K","Huisman MV","Hessels LM","Magdelijns FJH","Alnafie AN","Bemelmans RHH","Cornet A","Hovens MMC","Vlot EA","van Twist DJL","Visser C","Hajer GR","Croles FN","Brouwer RE","Putter H","Ruiz RM","van Montfort P","Tieleman RG","Hugtenburg JG","van der Linden MMJM","Ninaber MK","Langerak T","Weytjens C","Linschoten MPM","van der Heijden DJ","Kruip MJHA","Koning AMH","Zaal R","van der Horst ICC","Faber LM","van de Berg TW","Vlaar APJ","Siebelink HJ","den Uil CA","van Kesteren HAM","Reidinga AC","Schurgers LJ","Kempers EK","Tjong FVY","Olie RH","Klok FA","Messiaen P","Kamphuisen PW","Grootenboers MJJH","Poorhosseini H","Spaetgens B","Kroft LJM","Lijfering WM","Schrover IM","Bos MH","Gommers DAMPJ","Smits PC","van Guldener C","de Jager CPC","Coppens M","Kramers K","Raadsen MP","den Exter PL","Urbanus RT","van Boxem AJM","van Veen HPAA","Tuinman PR","Saxena M","van Gilst WH","Vink R","Drost JT","Schurink CAM","Tio RA","Versteeg HH","Tong-Minh K","Westerhof BD","Ferreira JB","Bruggeman RAG","Ten Berg JM","Ripley DP","Leentjes J","van Bussel BCT","Henskens YMC","Soei YL","Wolde MT","Muller MCA","Van Craenenbroeck EM","Faber J","Monraats PS","Ramai SRS","van Es N","Franken B","Sondermeijer BM","Faber HJ","Kleijwegt FS","Stals MAM","Nossent EJ","Kearney MT","Geersing GJ","Middeldorp S","Krabbe JG","Mulder MMG","Hertogh CMPM","Kevenaar ME","Rondon AMR","Roest T","van den Borst B","Cannegieter SC","Bruin S","Juffermans NP","Salah R","Delsing CE","Stads S","Nab L","Meijs DAM","Verschure DO","Aujayeb A","Kietselaer BLJH","Wu KW","Meijer K","Al-Muhanna FA","Simons KS","Groenemeijer BE","Kaasjager HAH","Festen B","Hermans-van Ast JF","Dutch Covid and Thrombosis Coalition & the CAPACITY-COVID collaborative consortium","Lansbergen A","Timmermans P","Meijs MFL","Tichelaar YIG","Meijers JCM","Kaptein FHJ","Emans ME","van den Biggelaar M","Zaman AG","van Gorp ECM","Saneei E","Maas C","Stam F","Nieuwenhuizen L","Captur G","Heunks LMA","Geelhoed JJM","Kant M","Montagna L","Nijziel MR","Spronk HMH","Dorman HGR","Ellerbroek JLJ","Shafiee A","Koster SCE","Schut A","Antoni ML","Schaap J","Westerink J","Prasad S","Woudstra P","Goeijenbier M","Tijmensen J","Endeman H","Vliegen HW","Pinto YM","de Jong CMM","Caputo M","Gabriel L","Jewbali LS","Laat B","Burggraaf JLI","van den Toorn LM","Heymans SRB","McCann GP","Moriarty A","Waal EGM","Eikenboom HCJ","van Vlijmen BJM","Mosterd A","Kwakkel-van Erp JM","Brouwer MC","van der Lee I","van der Zee PM","van Smeden M","Smulders YM","van Kooten J","van Haaps TF","Kuiken T","Smeets MJR","Linssen GCM","Shore AC","Wils EJ","De Sutter J","Schutgens REG","Paats MS","Boersma WG","Wierda E","Boutkourt F","Anthonio RL","van der Meer P","Oostdijk EAN","Alshahrani M","Cremer OL","Nijkeuter M","Dark P","Hunfeld NGM","van Ierssel SH","Ten Cate H","Roukens AHE","de Maat MPM","van Ofwegen-Hanekamp CEE","Ribeiro MIA","Bierings R","Voorberg J","Haerkens-Arends HE","Kopylov PY","van der Harst P","van de Wal RMA","Noordegraaf AV","de Haan LR","Westendorp ICD","Lisman T","Lauw MN","Tessitore E","le Cessie S","Charlotte N","Kuijper AFM","Hellou E","Redon J","Al-Windy NYY","van Hessen MWJ","Beishuizen A","Pisters R"],"additional_accession":[]},"is_claimable":false,"name":"Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis.","description":"Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on the optimal dosage of thromboprophylaxis in critically ill COVID-19 patients. We utilized data from the multicentre CAPACITY-COVID patient registry to assess the effect of differential application of Low Molecular Weight Heparin (LMWH) dose protocols on PE and in-hospital mortality risk in critically ill COVID-19 patients. An instrumental variable analysis was performed to estimate the intention-to-treat effect, utilizing differences in thromboprophylaxis prescribing behaviour between hospitals. We included 939 patients with PCR confirmed SARS-CoV-2 infection from 34 hospitals. Two-hundred-and-one ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-02T03:04:53.238Z","creation":"2025-07-02T03:04:53.238Z"},"accession":"S-EPMC11937556","cross_references":{"pubmed":["40133355"],"doi":["10.1038/s41598-024-77858-w"]}}