{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(4)"],"submitter":["Wang C"],"pubmed_abstract":["<h4>Background & aims</h4>Chronic HBV infection usually causes cirrhosis and hepatocellular carcinoma. Comparative investigations of acute and chronic HBV cases would help determine the immune responses crucial for viral clearance.<h4>Methods</h4>A fast-cleared HBV mouse model was established in Alb-Cre mice via hydrodynamic injection of HBV plasmid, while persistent HBV model mice were generated via recombinant covalently closed circular DNA-adeno-associated virus 8 infection. The single-cell transcriptomes of CD45<sup>+</sup> intrahepatic non-parenchymal cells from these mice were conducted. Multiplexed immunohistochemistry and flow cytometry were used to confirm the findings from single-cell transcriptomes. Transwell, coculture, and adoptive transfer experiments were performed to study "],"journal":["JHEP reports : innovation in hepatology"],"pagination":["101323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11937660"],"repository":["biostudies-literature"],"pubmed_title":["Potential role of liver-resident CD3&lt;sup&gt;+&lt;/sup&gt; macrophages in HBV clearance in a mouse hepatitis B model."],"pmcid":["PMC11937660"],"pubmed_authors":["Li Y","Wu M","Fang Z","Shi B","Wang C","Zhang X","Zai W","Zhao K","Zhou X","Yuan Z","Kozlowski M"],"additional_accession":[]},"is_claimable":false,"name":"Potential role of liver-resident CD3&lt;sup&gt;+&lt;/sup&gt; macrophages in HBV clearance in a mouse hepatitis B model.","description":"<h4>Background & aims</h4>Chronic HBV infection usually causes cirrhosis and hepatocellular carcinoma. Comparative investigations of acute and chronic HBV cases would help determine the immune responses crucial for viral clearance.<h4>Methods</h4>A fast-cleared HBV mouse model was established in Alb-Cre mice via hydrodynamic injection of HBV plasmid, while persistent HBV model mice were generated via recombinant covalently closed circular DNA-adeno-associated virus 8 infection. The single-cell transcriptomes of CD45<sup>+</sup> intrahepatic non-parenchymal cells from these mice were conducted. Multiplexed immunohistochemistry and flow cytometry were used to confirm the findings from single-cell transcriptomes. Transwell, coculture, and adoptive transfer experiments were performed to study ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-06-25T03:04:30.102Z","creation":"2025-06-25T03:04:30.102Z"},"accession":"S-EPMC11937660","cross_references":{"pubmed":["40143948"],"doi":["10.1016/j.jhepr.2024.101323"]}}