biostudies-literatureUnknown14(3)Hatem O<h4>Background</h4>Wine production generates significant amounts of grape marc, which can serve as a potential source of bioactive compounds, including polyphenols.<h4>Objectives</h4>In this study, we aimed to investigate the polyphenol content of skin and seeds separated from grape marc, and test their extracts against two significant bacteria, <i>Listeria monocytogenes</i> (<i>LM</i>) and <i>Staphylococcus aureus</i> (<i>SA</i>).<h4>Methods</h4>A comprehensive analysis of the phenolic composition in the skin, seeds, and juice/wine derived from Cabernet Sauvignon grape berries was conducted over an 18-day fermentation period. High-performance liquid chromatography was performed to identify and quantify the main flavan-3-ols, flavonols, anthocyanins, and stilbenes. In addition, the total pAntibiotics (Basel, Switzerland)236https://www.ebi.ac.uk/biostudies/studies/S-EPMC11939261biostudies-literatureInsight into the Phenolic Composition of Cabernet Sauvignon Grapevine Berries During Fermentation-Towards the Application of Winery By-Products for Antibacterial Purposes.PMC11939261Schneider GSzabo EKorosi LHatem OSeres-Steinbach AfalseInsight into the Phenolic Composition of Cabernet Sauvignon Grapevine Berries During Fermentation-Towards the Application of Winery By-Products for Antibacterial Purposes.<h4>Background</h4>Wine production generates significant amounts of grape marc, which can serve as a potential source of bioactive compounds, including polyphenols.<h4>Objectives</h4>In this study, we aimed to investigate the polyphenol content of skin and seeds separated from grape marc, and test their extracts against two significant bacteria, <i>Listeria monocytogenes</i> (<i>LM</i>) and <i>Staphylococcus aureus</i> (<i>SA</i>).<h4>Methods</h4>A comprehensive analysis of the phenolic composition in the skin, seeds, and juice/wine derived from Cabernet Sauvignon grape berries was conducted over an 18-day fermentation period. High-performance liquid chromatography was performed to identify and quantify the main flavan-3-ols, flavonols, anthocyanins, and stilbenes. In addition, the total p2025-01-01T00:00:00Z2025 Feb2025-06-25T03:04:38.69Z2025-06-25T03:04:38.69ZS-EPMC119392614014904710.3390/antibiotics14030236