{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Godinho PIC"],"funding":["Fundação para a Ciência e Tecnologia","Instituto de Salud Carlos III","European Union","Ministerio de Ciencia, Innovación y Universidades","Spanish Network for Research in Infectious Diseases"],"pagination":["218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11939745"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(3)"],"pubmed_abstract":["<b>Introduction/Objectives</b>: Nosocomial infections caused by <i>S. aureus</i> and <i>S. epidermidis</i> resistant strains are an important cause of morbidity and mortality worldwide. Due to the increasing rate of resistance to conventional antibiotics, the discovery of new antibiotic drugs is crucial to keep pace with the evolution of these pathogenic bacterial species. <b>Methods</b>: The 3-nitro-2<i>H</i>-chromene moiety is present in several compounds with potent antibacterial activity; based on these previous studies, we report herein the synthesis of 20 new 2-aryl-3-nitro-2<i>H</i>-chromene derivatives and the evaluation of their antibacterial potential in vitro. <b>Results</b>: Mono-halogenated nitrochromenes showed moderate anti-staphylococcal activity with MIC values of 8-32 μg/"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Halogenated 3-Nitro-2&lt;i&gt;H&lt;/i&gt;-Chromenes as Potential Agents Against Multidrug-Resistant Bacteria."],"pmcid":["PMC11939745"],"funding_grant_id":["AYUD/2022/9313","REIPI RD12/0015/0013 and REIPI RD16/0016/0010","PI22/00148","PID2022-137893OB-I00","UIDB/50006/2020","2022.11294.BD","RTI2018-099756-B-I00","PID2021-123964NB-I00"],"pubmed_authors":["Perez-Ramos P","Silva AMS","Gabasa Y","Soto SM","Godinho PIC","Cornielle E","Soengas RG"],"additional_accession":[]},"is_claimable":false,"name":"Halogenated 3-Nitro-2&lt;i&gt;H&lt;/i&gt;-Chromenes as Potential Agents Against Multidrug-Resistant Bacteria.","description":"<b>Introduction/Objectives</b>: Nosocomial infections caused by <i>S. aureus</i> and <i>S. epidermidis</i> resistant strains are an important cause of morbidity and mortality worldwide. Due to the increasing rate of resistance to conventional antibiotics, the discovery of new antibiotic drugs is crucial to keep pace with the evolution of these pathogenic bacterial species. <b>Methods</b>: The 3-nitro-2<i>H</i>-chromene moiety is present in several compounds with potent antibacterial activity; based on these previous studies, we report herein the synthesis of 20 new 2-aryl-3-nitro-2<i>H</i>-chromene derivatives and the evaluation of their antibacterial potential in vitro. <b>Results</b>: Mono-halogenated nitrochromenes showed moderate anti-staphylococcal activity with MIC values of 8-32 μg/","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-07-01T03:04:53.855Z","creation":"2025-07-01T03:04:53.855Z"},"accession":"S-EPMC11939745","cross_references":{"pubmed":["40149030"],"doi":["10.3390/antibiotics14030218"]}}