{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zebene ED"],"funding":["Ministero della Salute","International Atomic Energy Agency"],"pagination":["1010"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11940482"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(6)"],"pubmed_abstract":["<h4>Background</h4>Ionizing radiation (IR) exposure poses a significant health risk due to its widespread use in medical diagnostics and therapeutic applications, necessitating rapid and effective biomarkers for assessment.<h4>Objective</h4>The aim of this study is to identify the serum proteomic signature of IR exposure in patients undergoing radiotherapy (RT).<h4>Methods</h4>Blood samples were obtained from eighteen patients with head and neck cancer (HNC) and five patients with rectal cancer before and immediately after they underwent curative intensity-modulated radiotherapy (IMRT). The comprehensive serum proteome was analyzed in individual samples using nanoHPLC-MS/MS.<h4>Results</h4>Forty radiation-modulated proteins (RMPs), 24 upregulated and 16 downregulated, with a fold change ≥1"],"journal":["Cancers"],"pubmed_title":["Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure."],"pmcid":["PMC11940482"],"funding_grant_id":["RC2024 L2/2","ETH/6023"],"pubmed_authors":["Di Gennaro E","Woldemichael GB","Budillon A","Zebene ED","Medhin HT","Lombardi R","Pucci B","Seife E"],"additional_accession":[]},"is_claimable":false,"name":"Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure.","description":"<h4>Background</h4>Ionizing radiation (IR) exposure poses a significant health risk due to its widespread use in medical diagnostics and therapeutic applications, necessitating rapid and effective biomarkers for assessment.<h4>Objective</h4>The aim of this study is to identify the serum proteomic signature of IR exposure in patients undergoing radiotherapy (RT).<h4>Methods</h4>Blood samples were obtained from eighteen patients with head and neck cancer (HNC) and five patients with rectal cancer before and immediately after they underwent curative intensity-modulated radiotherapy (IMRT). The comprehensive serum proteome was analyzed in individual samples using nanoHPLC-MS/MS.<h4>Results</h4>Forty radiation-modulated proteins (RMPs), 24 upregulated and 16 downregulated, with a fold change ≥1","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-18T03:15:18.591Z","creation":"2025-07-10T03:08:33.424Z"},"accession":"S-EPMC11940482","cross_references":{"pubmed":["40149344"],"doi":["10.3390/cancers17061010"]}}