{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rendueles C"],"funding":["Ministerio de Ciencia, Innovación y Universidades"],"pagination":["2508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11942015"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(6)"],"pubmed_abstract":["Bacteriophages (or phages) remain the leading cause of failure in dairy fermentations. Thereby, phage-resistant <i>Lactococcus lactis</i> and <i>Lactococcus cremoris</i> dairy starters are in continuous demand. In this work, our goal was to identify phage defense mechanisms against ceduoviruses encoded by two wild isolates of dairy origin named <i>L. lactis</i> IPLA517 and IPLA1064. These strains were previously subjected to experimental evolution to select derivatives that are resistant to the bacteriocin Lcn972. It was observed that the Lcn972<sup>R</sup> derivatives became sensitive to phage infection; however, the underlying mechanism was not defined. The long-read sequencing technologies applied in this work reveal that all of the Lcn972<sup>R</sup> derivatives shared the loss of a 41"],"journal":["International journal of molecular sciences"],"pubmed_title":["A Plasmid-Encoded Surface Polysaccharide Partly Blocks &lt;i&gt;Ceduovirus&lt;/i&gt; Infection in Lactococci."],"pmcid":["PMC11942015"],"funding_grant_id":["PID2020-119697RB-I00"],"pubmed_authors":["Ruiz-Maso JA","Barra JL","Garay-Novillo JN","Rendueles C","Martinez B","Rau MH","Gaspar P","Mahony J","Rodriguez A","Del Solar G"],"additional_accession":[]},"is_claimable":false,"name":"A Plasmid-Encoded Surface Polysaccharide Partly Blocks &lt;i&gt;Ceduovirus&lt;/i&gt; Infection in Lactococci.","description":"Bacteriophages (or phages) remain the leading cause of failure in dairy fermentations. Thereby, phage-resistant <i>Lactococcus lactis</i> and <i>Lactococcus cremoris</i> dairy starters are in continuous demand. In this work, our goal was to identify phage defense mechanisms against ceduoviruses encoded by two wild isolates of dairy origin named <i>L. lactis</i> IPLA517 and IPLA1064. These strains were previously subjected to experimental evolution to select derivatives that are resistant to the bacteriocin Lcn972. It was observed that the Lcn972<sup>R</sup> derivatives became sensitive to phage infection; however, the underlying mechanism was not defined. The long-read sequencing technologies applied in this work reveal that all of the Lcn972<sup>R</sup> derivatives shared the loss of a 41","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-08T18:26:12.234Z","creation":"2025-06-25T03:04:24.609Z"},"accession":"S-EPMC11942015","cross_references":{"pubmed":["40141150"],"doi":["10.3390/ijms26062508"]}}