{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen D"],"funding":["National Key R&D Program of China"],"pagination":["2804"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11943016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(6)"],"pubmed_abstract":["In previous studies, we isolated a series of novel gentisides with nerve growth factor (NGF)-mimic activities from <i>Gentiana rigescens</i> Franch and conducted continuous structure-activity relationship (SAR) studies. Recently, a lead compound named TBG096 was discovered with significant NGF-mimic activity, low toxicity, and ability to pass through the blood-brain barrier (BBB). At the cell level, TBG096 exerts NGF-mimic activity by regulation of heat-shock cognate protein 70 (Hsc70) and downstream proteins. Subsequently, high-fat diet (HFD)-induced Alzheimer disease (AD) mouse models were used to evaluate the anti-AD efficacy of the compound. TBG096 significantly improved the memory dysfunction of AD mice at doses of 0.1, 5, and 20 mg/kg, respectively. In order to elucidate the mechanis"],"journal":["International journal of molecular sciences"],"pubmed_title":["TBG096 Ameliorates Memory Deficiency in AD Mouse Model via Promoting Neurogenesis and Regulation of Hsc70/HK2/PKM2/LAMP2A Signaling Pathway."],"pmcid":["PMC11943016"],"funding_grant_id":["2022YFE0104000"],"pubmed_authors":["Fasina OB","Qi J","Zeng J","Lin J","Manzoor M","Ohno H","Xiang L","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"TBG096 Ameliorates Memory Deficiency in AD Mouse Model via Promoting Neurogenesis and Regulation of Hsc70/HK2/PKM2/LAMP2A Signaling Pathway.","description":"In previous studies, we isolated a series of novel gentisides with nerve growth factor (NGF)-mimic activities from <i>Gentiana rigescens</i> Franch and conducted continuous structure-activity relationship (SAR) studies. Recently, a lead compound named TBG096 was discovered with significant NGF-mimic activity, low toxicity, and ability to pass through the blood-brain barrier (BBB). At the cell level, TBG096 exerts NGF-mimic activity by regulation of heat-shock cognate protein 70 (Hsc70) and downstream proteins. Subsequently, high-fat diet (HFD)-induced Alzheimer disease (AD) mouse models were used to evaluate the anti-AD efficacy of the compound. TBG096 significantly improved the memory dysfunction of AD mice at doses of 0.1, 5, and 20 mg/kg, respectively. In order to elucidate the mechanis","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-02T03:04:46.55Z","creation":"2025-07-02T03:04:46.55Z"},"accession":"S-EPMC11943016","cross_references":{"pubmed":["40141445"],"doi":["10.3390/ijms26062804"]}}