biostudies-literatureHanif NIndonesia Endowment Fund for Education Agency (LPDP) and National Research and Innovation Agency (BRIN) of the Republic of Indonesia1202https://www.ebi.ac.uk/biostudies/studies/S-EPMC11944283biostudies-literatureUnknown30(6)Microorganisms play a significant role in biofouling and biocorrosion within the maritime industry. Addressing these challenges requires an innovative and integrated approach utilizing marine natural products with beneficial properties. A comprehensive screening of 173 non-toxic EtOAc and H₂O extracts derived from diverse marine organisms collected in Indonesian waters was conducted using a robust panel of assays. These included antimicrobial tests and classical biosurfactant assays (drop collapse and oil displacement), as well as anti-quorum-sensing (QS) and anti-biofilm assays. These screening efforts identified five active extracts with promising activities. Among these, EtOAc extracts of the marine tunicate <i>Sigilina</i> cf. <i>signifera</i> (0159-22e) and the marine sponge <i>LamellMolecules (Basel, Switzerland)Integrated Biological and Chemical Investigation of Indonesian Marine Organisms Targeting Anti-Quorum-Sensing, Anti-Biofilm, Anti-Biofouling, and Anti-Biocorrosion Activities.PMC11944283106/IV/KS/11/2023, 41644/IT3/PT.01.03/P/B/2023, 1/PEE-2/PPK-DFRI/2022, and 7197/IT3.L1PT.01.Miftah JAKjelleberg SHanif NMurni ATan LTKundukad BZahra VASalleh NFJaspars MYanti HDNoviendri DOluwabusola ETVoogd NJTanaka JRachmania NfalseIntegrated Biological and Chemical Investigation of Indonesian Marine Organisms Targeting Anti-Quorum-Sensing, Anti-Biofilm, Anti-Biofouling, and Anti-Biocorrosion Activities.Microorganisms play a significant role in biofouling and biocorrosion within the maritime industry. Addressing these challenges requires an innovative and integrated approach utilizing marine natural products with beneficial properties. A comprehensive screening of 173 non-toxic EtOAc and H₂O extracts derived from diverse marine organisms collected in Indonesian waters was conducted using a robust panel of assays. These included antimicrobial tests and classical biosurfactant assays (drop collapse and oil displacement), as well as anti-quorum-sensing (QS) and anti-biofilm assays. These screening efforts identified five active extracts with promising activities. Among these, EtOAc extracts of the marine tunicate <i>Sigilina</i> cf. <i>signifera</i> (0159-22e) and the marine sponge <i>Lamell2025-01-01T00:00:00Z2025 Mar2026-05-23T03:10:54.432Z2026-05-23T03:08:03.078ZS-EPMC119442834014198310.3390/molecules30061202