{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu Y"],"funding":["Shandong Province Modern Agricultural Technology System Donkey Industrial Innovation Team","Natural Science Foundation of Shandong Province","Project of Shandong Province Higher Educational Science and Technology Program for Youth","he Innovation and Entrepreneurship Program for College Students"],"pagination":["347"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11945448"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(3)"],"pubmed_abstract":["Equid alphaherpesvirus type 8 (EHV-8) is a contagious pathogen that causes reproductive disorders, respiratory diseases, and viral encephalitis in equids, resulting in significant economic losses for the global horse and donkey industries. Currently, there are no approved antiviral drugs or vaccines available for EHV-8 control. In this study, we investigated the antiviral efficacy of celastrol against EHV-8 both in vitro and in vivo. Our results demonstrated that celastrol significantly inhibited EHV-8 infection in Rabbit kidney (RK-13) and equine dermal cells (NBL-6) in a dose-dependent manner. Mechanistic studies revealed that celastrol interfered with viral replication at multiple stages of the infection cycle. Furthermore, we found that celastrol induced an antiviral interferon respons"],"journal":["Viruses"],"pubmed_title":["Evaluation of Celastrol Antiviral Activity Against Equid Alphaherpesvirus Type 8 Infection."],"pmcid":["PMC11945448"],"funding_grant_id":["ZR2024MC16","2022KJ287","SDAIT-27, SDAIT-27-04,SDAIT-27-17","CXCY2022434"],"pubmed_authors":["Ren H","Wang C","Ruan L","Chen L","Khan MZ","Wang T","You A","Wang J","Li L","Yu Y","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of Celastrol Antiviral Activity Against Equid Alphaherpesvirus Type 8 Infection.","description":"Equid alphaherpesvirus type 8 (EHV-8) is a contagious pathogen that causes reproductive disorders, respiratory diseases, and viral encephalitis in equids, resulting in significant economic losses for the global horse and donkey industries. Currently, there are no approved antiviral drugs or vaccines available for EHV-8 control. In this study, we investigated the antiviral efficacy of celastrol against EHV-8 both in vitro and in vivo. Our results demonstrated that celastrol significantly inhibited EHV-8 infection in Rabbit kidney (RK-13) and equine dermal cells (NBL-6) in a dose-dependent manner. Mechanistic studies revealed that celastrol interfered with viral replication at multiple stages of the infection cycle. Furthermore, we found that celastrol induced an antiviral interferon respons","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-05-23T03:11:24.341Z","creation":"2025-07-13T03:04:30.081Z"},"accession":"S-EPMC11945448","cross_references":{"pubmed":["40143276"],"doi":["10.3390/v17030347"]}}