{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang S"],"funding":["\"Grassland Talents\" Scholar Program","Inner Mongolia Science and Technology Plan","\"High-Level Overseas Talents\" Project","State Key Laboratory for Reproductive Regulation and Breeding of Grassland Livestock","Xilingol Science and Technology Plan","\"High-level Talents\" Import Program of the Inner Mongolia University"],"pagination":["222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11945889"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["Reproductive performance in sheep plays a crucial role in determining the economic efficiency of the industry, with increasing litter size being a key focus for genetic improvement. The <i>BMP15</i> gene is widely recognized as a major gene influencing sheep fertility. In this study, specific mutations in the <i>BMP15</i> gene of Gobi short tail sheep were identified through direct sequencing, and these mutations were genotyped using the MassARRAY system. The g.54285159_54285161TTA indel was significantly associated with litter size in Gobi short tail sheep (<i>p</i> < 0.05). Three mutations, including g.54291460G>A, g.54288671C>T, and the g.54285159_54285161TTA indel, were significantly associated with litter size in Ujimqin sheep (<i>p</i> < 0.05). Furthermore, the promoter activity anal"],"journal":["Veterinary sciences"],"pubmed_title":["Variants in &lt;i&gt;BMP15&lt;/i&gt; Gene Affect Promoter Activity and Litter Size in Gobi Short Tail and Ujimqin Sheep."],"pmcid":["PMC11945889"],"funding_grant_id":["GD202210","2021ZD0046","2021ZZ0204","21400-5165112","CYYC6068","[2018] No. 190","2024SKYPT0068"],"pubmed_authors":["Tong B","Jin H","Li C","Cao G","Wang S","Wang D","Du G","Zhang M","Cang M","Bai Y","Alatan S"],"additional_accession":[]},"is_claimable":false,"name":"Variants in &lt;i&gt;BMP15&lt;/i&gt; Gene Affect Promoter Activity and Litter Size in Gobi Short Tail and Ujimqin Sheep.","description":"Reproductive performance in sheep plays a crucial role in determining the economic efficiency of the industry, with increasing litter size being a key focus for genetic improvement. The <i>BMP15</i> gene is widely recognized as a major gene influencing sheep fertility. In this study, specific mutations in the <i>BMP15</i> gene of Gobi short tail sheep were identified through direct sequencing, and these mutations were genotyped using the MassARRAY system. The g.54285159_54285161TTA indel was significantly associated with litter size in Gobi short tail sheep (<i>p</i> < 0.05). Three mutations, including g.54291460G>A, g.54288671C>T, and the g.54285159_54285161TTA indel, were significantly associated with litter size in Ujimqin sheep (<i>p</i> < 0.05). Furthermore, the promoter activity anal","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-23T03:21:40.463Z","creation":"2025-07-09T03:04:44.616Z"},"accession":"S-EPMC11945889","cross_references":{"pubmed":["40266917"],"doi":["10.3390/vetsci12030222"]}}