{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Sun D"],"pubmed_abstract":["The treatment of gastric cancer remains challenging, with immunotherapy serving as a critical component of the holistic approach to its treatment. The results of this study indicated that statins could decrease the serum levels of interleukin-enhancing binding factor 3 (ILF3) and programmed cell death ligand 1(PD-L1) in GC patients and improve their prognosis. Functional experiments demonstrated that simvastatin induced ferroptosis by inhibiting ILF3 in GC cells and enhanced the killing effect of activated CD8<sup>+</sup> T cells on GC cells. The CUT&Tag assay revealed that, mechanistically, simvastatin inhibited ILF3 expression by reducing the acetylation level at residue site H3K14 in ILF3. Next-generation sequencing and Kyoto Encyclopedia of Genes and Genomes analysis revealed that ILF3"],"journal":["Cell death & disease"],"pagination":["208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11947124"],"repository":["biostudies-literature"],"pubmed_title":["Simvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells."],"pmcid":["PMC11947124"],"pubmed_authors":["Yang W","Wei M","Yan Z","Sun D","Cui X","Yu W","Zhang M"],"additional_accession":[]},"is_claimable":false,"name":"Simvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells.","description":"The treatment of gastric cancer remains challenging, with immunotherapy serving as a critical component of the holistic approach to its treatment. The results of this study indicated that statins could decrease the serum levels of interleukin-enhancing binding factor 3 (ILF3) and programmed cell death ligand 1(PD-L1) in GC patients and improve their prognosis. Functional experiments demonstrated that simvastatin induced ferroptosis by inhibiting ILF3 in GC cells and enhanced the killing effect of activated CD8<sup>+</sup> T cells on GC cells. The CUT&Tag assay revealed that, mechanistically, simvastatin inhibited ILF3 expression by reducing the acetylation level at residue site H3K14 in ILF3. Next-generation sequencing and Kyoto Encyclopedia of Genes and Genomes analysis revealed that ILF3","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-02T03:04:43.299Z","creation":"2025-07-02T03:04:43.299Z"},"accession":"S-EPMC11947124","cross_references":{"pubmed":["40140647"],"doi":["10.1038/s41419-025-07562-8"]}}