{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen G"],"funding":["US National Institutes of Health grant","the STI2030-Major Projects","National Natural Science Foundation of China","Beijing Chao-Yang Hospital Multidisciplinary Team Program","R&D Program of the Beijing Municipal Education Commission","Shenzhen Bay Scholars Program and Tianchi Scholars Program","Sino-German Cooperation"],"pagination":["e70089"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11947737"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(3)"],"pubmed_abstract":["<h4>Introduction</h4>Water exchange rate (Kw) across the blood-brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations in BBB Kw across the Alzheimer's disease (AD) continuum remain uncertain.<h4>Methods</h4>The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A-), 30 cognitively normal (CN_A+), and 31 cognitively impaired individuals (CI_A+) with positive AD biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, and assays of plasma biomarkers.<h4>Results</h4>Significantly lower Kw was observed in multiple brain regions throughout the AD continuum. This alteration in Kw correlated with plasma biomarkers and neuropsychological performance. Elevated levels of p"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Decreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data."],"pmcid":["PMC11947737"],"funding_grant_id":["2022ZD0211800","NSFC 82025018","82401661","KM202310025013","82020108013","82327809","CYDXK202201","R01NS114382","M-0759","CYDXK202207"],"pubmed_authors":["Li H","Shao X","Wang DJJ","Hu W","Chen G","Han Y","Yang Q"],"additional_accession":[]},"is_claimable":false,"name":"Decreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data.","description":"<h4>Introduction</h4>Water exchange rate (Kw) across the blood-brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations in BBB Kw across the Alzheimer's disease (AD) continuum remain uncertain.<h4>Methods</h4>The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A-), 30 cognitively normal (CN_A+), and 31 cognitively impaired individuals (CI_A+) with positive AD biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, and assays of plasma biomarkers.<h4>Results</h4>Significantly lower Kw was observed in multiple brain regions throughout the AD continuum. This alteration in Kw correlated with plasma biomarkers and neuropsychological performance. Elevated levels of p","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-04T03:05:46.534Z","creation":"2025-07-04T03:05:46.534Z"},"accession":"S-EPMC11947737","cross_references":{"pubmed":["40145328"],"doi":["10.1002/alz.70089"]}}