biostudies-literatureChen GUS National Institutes of Health grantthe STI2030-Major ProjectsNational Natural Science Foundation of ChinaBeijing Chao-Yang Hospital Multidisciplinary Team ProgramR&D Program of the Beijing Municipal Education CommissionShenzhen Bay Scholars Program and Tianchi Scholars ProgramSino-German Cooperatione70089https://www.ebi.ac.uk/biostudies/studies/S-EPMC11947737biostudies-literatureUnknown21(3)<h4>Introduction</h4>Water exchange rate (Kw) across the blood-brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations in BBB Kw across the Alzheimer's disease (AD) continuum remain uncertain.<h4>Methods</h4>The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A-), 30 cognitively normal (CN_A+), and 31 cognitively impaired individuals (CI_A+) with positive AD biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, and assays of plasma biomarkers.<h4>Results</h4>Significantly lower Kw was observed in multiple brain regions throughout the AD continuum. This alteration in Kw correlated with plasma biomarkers and neuropsychological performance. Elevated levels of pAlzheimer's & dementia : the journal of the Alzheimer's AssociationDecreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data.PMC119477372022ZD0211800NSFC 8202501882401661KM2023100250138202010801382327809CYDXK202201R01NS114382M-0759CYDXK202207Li HShao XWang DJJHu WChen GHan YYang QfalseDecreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data.<h4>Introduction</h4>Water exchange rate (Kw) across the blood-brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations in BBB Kw across the Alzheimer's disease (AD) continuum remain uncertain.<h4>Methods</h4>The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A-), 30 cognitively normal (CN_A+), and 31 cognitively impaired individuals (CI_A+) with positive AD biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, and assays of plasma biomarkers.<h4>Results</h4>Significantly lower Kw was observed in multiple brain regions throughout the AD continuum. This alteration in Kw correlated with plasma biomarkers and neuropsychological performance. Elevated levels of p2025-01-01T00:00:00Z2025 Mar2025-07-04T03:05:46.534Z2025-07-04T03:05:46.534ZS-EPMC119477374014532810.1002/alz.70089