biostudies-literatureUnknown10(11)Li H<i>Candida</i> vaginitis (CV) is the most common fungal infection among gynecological diseases, caused by <i>Candida albicans</i> (<i>C. albicans</i>). Traditional treatment for CV has led to increased antibiotic resistance, complicating treatment and indiscriminately killing both pathogens and beneficial bacteria in the vagina. Additionally, the inconvenience of traditional vaginal administration and the short residence time of treatments pose significant challenges. We developed a safe and effective combination drug delivery platform featuring magnetic bilayer gel microspheres to combine antibacterial properties and maintain the balance of the microbial community. This platform was characterized through a series of <i>in vitro</i> tests evaluating its dissolution, adherence, and retentioACS omega11282-11295https://www.ebi.ac.uk/biostudies/studies/S-EPMC11947829biostudies-literatureDouble-Layer Magnetic Microspheres with Dual Drug Delivery of Antibacterial and Maintenance Agents for the Treatment of <i>Candida albicans</i> Vaginitis.PMC11947829Zou XLv ZLi HGui SJin XLu XTian HHuang HXu SXin HYao XXu YfalseDouble-Layer Magnetic Microspheres with Dual Drug Delivery of Antibacterial and Maintenance Agents for the Treatment of <i>Candida albicans</i> Vaginitis.<i>Candida</i> vaginitis (CV) is the most common fungal infection among gynecological diseases, caused by <i>Candida albicans</i> (<i>C. albicans</i>). Traditional treatment for CV has led to increased antibiotic resistance, complicating treatment and indiscriminately killing both pathogens and beneficial bacteria in the vagina. Additionally, the inconvenience of traditional vaginal administration and the short residence time of treatments pose significant challenges. We developed a safe and effective combination drug delivery platform featuring magnetic bilayer gel microspheres to combine antibacterial properties and maintain the balance of the microbial community. This platform was characterized through a series of <i>in vitro</i> tests evaluating its dissolution, adherence, and retentio2025-01-01T00:00:00Z2025 Mar2025-07-05T03:05:31.042Z2025-07-05T03:05:31.042ZS-EPMC119478294016073110.1021/acsomega.4c11016