biostudies-literatureUnknown8(3)Springer MV<h4>Importance</h4>Acute stroke is associated with accelerated, years-long cognitive decline. Whether education levels are associated with faster cognitive decline after stroke is unclear.<h4>Objective</h4>To evaluate the association of education level with poststroke cognitive decline and to determine whether age at stroke modifies the association.<h4>Design, setting, and participants</h4>Individual participant data meta-analysis of 4 US cohort studies (January 1971 to December 2019). Analysis began August 2022 and was completed in January 2024.<h4>Exposures</h4>Education level (less than high school, completed high school, some college, and college graduate).<h4>Main outcomes and measures</h4>Harmonized cognitive outcomes were global cognition (primary outcome), memory, and executive funJAMA network opene252002https://www.ebi.ac.uk/biostudies/studies/S-EPMC11947833biostudies-literatureEducation Levels and Poststroke Cognitive Trajectories.PMC11947833Burke JFFerber RAYe WGross ALLevine DABriceno EMLongstreth WTWhitney RTHoward VJKollipara ASBeiser ASSussman JBGottesman RFLazar RMKoton SElkind MSVHayward RAGiordani BPendlebury STAparicio HJThacker ELSpringer MVfalseEducation Levels and Poststroke Cognitive Trajectories.<h4>Importance</h4>Acute stroke is associated with accelerated, years-long cognitive decline. Whether education levels are associated with faster cognitive decline after stroke is unclear.<h4>Objective</h4>To evaluate the association of education level with poststroke cognitive decline and to determine whether age at stroke modifies the association.<h4>Design, setting, and participants</h4>Individual participant data meta-analysis of 4 US cohort studies (January 1971 to December 2019). Analysis began August 2022 and was completed in January 2024.<h4>Exposures</h4>Education level (less than high school, completed high school, some college, and college graduate).<h4>Main outcomes and measures</h4>Harmonized cognitive outcomes were global cognition (primary outcome), memory, and executive fun2025-01-01T00:00:00Z2025 Mar2025-07-04T03:05:47.958Z2025-07-04T03:05:47.958ZS-EPMC119478334013630010.1001/jamanetworkopen.2025.2002