{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vanichapol T"],"funding":["NIDDK NIH HHS","NIDDK"],"pagination":["e187008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11949033"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(5)"],"pubmed_abstract":["Urinary obstruction causes injury to the renal medulla, impairing the ability to concentrate urine and increasing the risk of progressive kidney disease. However, the regenerative capacity of the renal medulla after reversal of obstruction is poorly understood. To investigate this, we developed a mouse model of reversible urinary obstruction. Despite robust regeneration and complete histological recovery of the renal medulla, these mice exhibited a permanent defect in urinary concentrating capacity. However, there were lasting changes in the composition, organization, and transcriptional profiles of epithelial, endothelial, and interstitial cells. Persistent inflammatory responses were also seen in patients with renal stone disease, but there were also adaptive responses to the increasingl"],"journal":["JCI insight"],"pubmed_title":["Permanent defects in renal medullary structure and function after reversal of urinary obstruction."],"pmcid":["PMC11949033"],"funding_grant_id":["U54 DK120058","R01 DK128823","R01 DK112688","UC2DK126122","UC2 DK126122","RO1DK128823"],"pubmed_authors":["Snyder WE","Yang H","de Caestecker MP","Sander V","Brewer M","Rahman T","Clouthier KA","Delgado R","Vanichapol T","Gonzalez A","Davidson AJ","Menshikh AA"],"additional_accession":[]},"is_claimable":false,"name":"Permanent defects in renal medullary structure and function after reversal of urinary obstruction.","description":"Urinary obstruction causes injury to the renal medulla, impairing the ability to concentrate urine and increasing the risk of progressive kidney disease. However, the regenerative capacity of the renal medulla after reversal of obstruction is poorly understood. To investigate this, we developed a mouse model of reversible urinary obstruction. Despite robust regeneration and complete histological recovery of the renal medulla, these mice exhibited a permanent defect in urinary concentrating capacity. However, there were lasting changes in the composition, organization, and transcriptional profiles of epithelial, endothelial, and interstitial cells. Persistent inflammatory responses were also seen in patients with renal stone disease, but there were also adaptive responses to the increasingl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-01T19:09:54.511Z","creation":"2026-05-19T03:07:08.504Z"},"accession":"S-EPMC11949033","cross_references":{"pubmed":["39847447"],"doi":["10.1172/jci.insight.187008"]}}