{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kak G"],"funding":["National Institute of Allergy and Infectious Diseases","National Institute of Neurological Disorders and Stroke","NIAID NIH HHS","NCI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["e183327"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11949042"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["Access to the brain for treating neurological sequalae requires a craniotomy, which can be complicated by infection. Staphylococcus aureus accounts for half of craniotomy infections, increasing morbidity in a medically fragile patient population. T cells preferentially traffic to the brain during craniotomy infection; however, their functional importance is unknown. Using a mouse model of S. aureus craniotomy infection, CD4+ T cells were critical for bacterial containment, as treatment of WT animals with anti-CD4 exacerbated infection that was similar to phenotypes in Rag1-/- mice. Single-cell RNA-Seq (scRNA-Seq) revealed transcriptional heterogeneity in brain CD3+ infiltrates, with CD4+ cells most prominent that displayed Th1- and Th17-like characteristics, and adoptive transfer of either"],"journal":["JCI insight"],"pubmed_title":["CD4+ T cell-innate immune crosstalk is critical during Staphylococcus aureus craniotomy infection."],"pmcid":["PMC11949042"],"funding_grant_id":["P30 CA036727","R01 AI169788","F32 NS126302","P30 GM110768","P20 GM103427"],"pubmed_authors":["Kak G","Fallet RW","Van Roy Z","Kielian T","Korshoj LE"],"additional_accession":[]},"is_claimable":false,"name":"CD4+ T cell-innate immune crosstalk is critical during Staphylococcus aureus craniotomy infection.","description":"Access to the brain for treating neurological sequalae requires a craniotomy, which can be complicated by infection. Staphylococcus aureus accounts for half of craniotomy infections, increasing morbidity in a medically fragile patient population. T cells preferentially traffic to the brain during craniotomy infection; however, their functional importance is unknown. Using a mouse model of S. aureus craniotomy infection, CD4+ T cells were critical for bacterial containment, as treatment of WT animals with anti-CD4 exacerbated infection that was similar to phenotypes in Rag1-/- mice. Single-cell RNA-Seq (scRNA-Seq) revealed transcriptional heterogeneity in brain CD3+ infiltrates, with CD4+ cells most prominent that displayed Th1- and Th17-like characteristics, and adoptive transfer of either","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-02T17:29:48.449Z","creation":"2025-06-25T03:04:38.457Z"},"accession":"S-EPMC11949042","cross_references":{"pubmed":["39989461"],"doi":["10.1172/jci.insight.183327"]}}