{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li C"],"funding":["NCI NIH HHS","National Cancer Institute of the National Institutes of Health"],"pagination":["e186344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11949068"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(5)"],"pubmed_abstract":["Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse and improving outcomes. We identify SUV39H1, a histone-3, lysine-9 methyltransferase, as critical for GSC maintenance and GBM progression. SUV39H1 is upregulated in GBM compared with normal brain tissues, with single-cell RNA-seq showing its expression predominantly in GSCs due to super-enhancer-mediated activation. Knockdown of SUV39H1 in GSCs impaired their proliferation and stemness. Whole-cell RNA-seq analysis revealed that SUV39H1 regulates G2/M cell cycle progression, stem cell maintenance, and cell death pathways in GSCs. By integrating the RNA-seq data with ATAC-seq data, we further demo"],"journal":["JCI insight"],"pubmed_title":["SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma."],"pmcid":["PMC11949068"],"funding_grant_id":["P30CA030199","R01 CA231349","P30 CA082709","P30 CA030199"],"pubmed_authors":["Shen J","Li C","Wang YA","Spruck C","Huang TY","Du Y","Xie Q","Nephew KP","Cao B","Ghosh S","Vo GV","Carpenter RL","Lu QR"],"additional_accession":[]},"is_claimable":false,"name":"SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma.","description":"Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse and improving outcomes. We identify SUV39H1, a histone-3, lysine-9 methyltransferase, as critical for GSC maintenance and GBM progression. SUV39H1 is upregulated in GBM compared with normal brain tissues, with single-cell RNA-seq showing its expression predominantly in GSCs due to super-enhancer-mediated activation. Knockdown of SUV39H1 in GSCs impaired their proliferation and stemness. Whole-cell RNA-seq analysis revealed that SUV39H1 regulates G2/M cell cycle progression, stem cell maintenance, and cell death pathways in GSCs. By integrating the RNA-seq data with ATAC-seq data, we further demo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-02T06:33:12.862Z","creation":"2025-07-11T03:03:56.419Z"},"accession":"S-EPMC11949068","cross_references":{"pubmed":["40059829"],"doi":["10.1172/jci.insight.186344"]}}