{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Veuskens BRJ"],"funding":["Sanquin Research Fund","European Union's Horizon 2020 research and innovation programme"],"pagination":["10669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11950314"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Factor H-related (FHR) protein 1 and 2 form dimers resulting in FHR-1 and -2 homodimers, and FHR-1/2 heterodimers. Dimerization is hypothesized to further increase their antagonistic function with complement regulator factor H (FH). So far, only FHR-1 homodimers and FHR-1/2 heterodimers could be quantified in a direct way. With the reported genetic associations between CFHR2 and complement-related diseases such as age related macular degeneration and C3-glomerulopathy, direct assessment of FHR-2/2 levels determining the dimer distribution of FHR-1 and -2 is needed to further elucidate their role within complement regulation. Therefore, novel in-house generated FHR-2 antibodies were used to develop a specific ELISA to enable direct quantification of FHR-2 homodimers. Allowing for the first "],"journal":["Scientific reports"],"pubmed_title":["Factor H-related 2 levels dictate FHR dimer composition."],"pmcid":["PMC11950314"],"funding_grant_id":["899163","SRF-YIA-23-06"],"pubmed_authors":["Brouwer MC","Keijzer NCH","van Mierlo G","Veuskens BRJ","Hoogenboezem M","Pouw RB","Geissler J","van Leeuwen K","Derlagen M","Kuijpers TW"],"additional_accession":[]},"is_claimable":false,"name":"Factor H-related 2 levels dictate FHR dimer composition.","description":"Factor H-related (FHR) protein 1 and 2 form dimers resulting in FHR-1 and -2 homodimers, and FHR-1/2 heterodimers. Dimerization is hypothesized to further increase their antagonistic function with complement regulator factor H (FH). So far, only FHR-1 homodimers and FHR-1/2 heterodimers could be quantified in a direct way. With the reported genetic associations between CFHR2 and complement-related diseases such as age related macular degeneration and C3-glomerulopathy, direct assessment of FHR-2/2 levels determining the dimer distribution of FHR-1 and -2 is needed to further elucidate their role within complement regulation. Therefore, novel in-house generated FHR-2 antibodies were used to develop a specific ELISA to enable direct quantification of FHR-2 homodimers. Allowing for the first ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-03T02:35:31.689Z","creation":"2025-07-09T03:04:32.341Z"},"accession":"S-EPMC11950314","cross_references":{"pubmed":["40148491"],"doi":["10.1038/s41598-025-94064-4"]}}