{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Vette SPM"],"funding":["NIDCR NIH HHS","NCI NIH HHS","ZonMw"],"pagination":["107224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11950982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["163"],"pubmed_abstract":["Background/purpose
Normal tissue complication probability (NTCP) models can be used to guide radiation therapy (RT) decisions by estimating side-effect risks pretreatment to minimize (late) side-effects. Recently, a comprehensive individual toxicity risk (CITOR) profile of NTCP models addressing common side-effects in head and neck cancer (HNC) patients was developed. This study investigates the generalizability of these models in an international setting, with different treatment approaches and side-effect assessments, promoting their integration into more widespread clinical practice.Materials/methods
From a prospective registry study, 407 HNC patients were included who were treated with definitive RT with or without systemic therapy between 2015 and 2022. NTCP models pre"],"journal":["Oral oncology"],"pubmed_title":["Evaluation of a comprehensive set of normal tissue complication probability models for patients with head and neck cancer in an international cohort."],"pmcid":["PMC11950982"],"funding_grant_id":["P01 CA285249","P30 CA016672","R01 CA258827","R21 CA273984","R01 DE028290","K01 DE030524","09150162010173","R01 CA257814"],"pubmed_authors":["Steenbakkers RJHM","van Dijk LV","de Vette SPM","Van den Bosch L","Neh H","Frederiks ML","Heukelom J","van Rijn-Dekker MI","Fuller CD","Hutcheson KA","Keijzer K","van der Schaaf A","Sijtsema NM","Langendijk JA","van Luijk P","Li Y","Moreno AC","Chu H","van der Laan HP"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of a comprehensive set of normal tissue complication probability models for patients with head and neck cancer in an international cohort.","description":"Background/purpose
Normal tissue complication probability (NTCP) models can be used to guide radiation therapy (RT) decisions by estimating side-effect risks pretreatment to minimize (late) side-effects. Recently, a comprehensive individual toxicity risk (CITOR) profile of NTCP models addressing common side-effects in head and neck cancer (HNC) patients was developed. This study investigates the generalizability of these models in an international setting, with different treatment approaches and side-effect assessments, promoting their integration into more widespread clinical practice.Materials/methods
From a prospective registry study, 407 HNC patients were included who were treated with definitive RT with or without systemic therapy between 2015 and 2022. NTCP models pre","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-01T14:42:59.666Z","creation":"2026-04-08T13:24:15.444Z"},"accession":"S-EPMC11950982","cross_references":{"pubmed":["40023984"],"doi":["10.1016/j.oraloncology.2025.107224"]}}