{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu S"],"funding":["National Natural Science Foundation of China"],"pagination":["103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11951540"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>The immediate perioperative period (IPP) usually is highly stressful and has significant effects on the postoperative recurrence/metastasis of tumors. Effective methods for limiting the impact of the IPP on postoperative recurrence/metastasis of tumors remain scarce. We aimed to determine the effects of dexmedetomidine (DEX) treatment during the IPP on postoperative recurrence/metastasis of tumors and the stress response.<h4>Materials and methods</h4>The clinical perioperative setting was mimicked via tumor resection and perioperative restraint stress in tumor-bearing mice with or without DEX during the IPP. The stress response was assessed using stress hormone and interleukin (IL)-6 levels in peripheral blood. Tumor cell growth was measured via in vivo bioluminescent im"],"journal":["World journal of surgical oncology"],"pubmed_title":["Dexmedetomidine alleviates the pro-tumor activity of perioperative stress in tumor-bearing mice: an alternative approach of psycho-physiological intervention."],"pmcid":["PMC11951540"],"funding_grant_id":["N0.81870861"],"pubmed_authors":["Tong J","Xu S","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Dexmedetomidine alleviates the pro-tumor activity of perioperative stress in tumor-bearing mice: an alternative approach of psycho-physiological intervention.","description":"<h4>Background</h4>The immediate perioperative period (IPP) usually is highly stressful and has significant effects on the postoperative recurrence/metastasis of tumors. Effective methods for limiting the impact of the IPP on postoperative recurrence/metastasis of tumors remain scarce. We aimed to determine the effects of dexmedetomidine (DEX) treatment during the IPP on postoperative recurrence/metastasis of tumors and the stress response.<h4>Materials and methods</h4>The clinical perioperative setting was mimicked via tumor resection and perioperative restraint stress in tumor-bearing mice with or without DEX during the IPP. The stress response was assessed using stress hormone and interleukin (IL)-6 levels in peripheral blood. Tumor cell growth was measured via in vivo bioluminescent im","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-18T03:14:48.907Z","creation":"2025-07-10T03:08:19.891Z"},"accession":"S-EPMC11951540","cross_references":{"pubmed":["40156037"],"doi":["10.1186/s12957-025-03665-w"]}}