{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(13)"],"submitter":["Page CK"],"pubmed_abstract":["The two influenza B virus (FLUBV) lineages have continuously diverged from each other since the 1980s, with recent (post-2015) viruses exhibiting accelerated evolutionary rates. Emerging data from human studies and epidemiological models suggest that increased divergence in contemporary viruses may drive differential cross-protection, where infection with Yamagata lineage viruses provides limited immunity against Victoria lineage viruses. Here, we developed animal models to investigate the mechanisms behind asymmetric cross-protection between contemporary FLUBV lineages. Our results show that contemporary Victoria immunity provides robust cross-protection against the Yamagata lineage, whereas Yamagata immunity offers limited protection against the Victoria lineage. This differential cross-"],"journal":["Science advances"],"pagination":["eadu3344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11952091"],"repository":["biostudies-literature"],"pubmed_title":["Neuraminidase-specific antibodies drive differential cross-protection between contemporary FLUBV lineages."],"pmcid":["PMC11952091"],"pubmed_authors":["Shepard JD","Rowe-Haas DK","Page CK","Rodriguez AJ","Tompkins SM","Akinpelu JY","Jacob JC","Hertz T","Han J","Ray SD","Ferguson JA","Friedman LM","Ward AB"],"additional_accession":[]},"is_claimable":false,"name":"Neuraminidase-specific antibodies drive differential cross-protection between contemporary FLUBV lineages.","description":"The two influenza B virus (FLUBV) lineages have continuously diverged from each other since the 1980s, with recent (post-2015) viruses exhibiting accelerated evolutionary rates. Emerging data from human studies and epidemiological models suggest that increased divergence in contemporary viruses may drive differential cross-protection, where infection with Yamagata lineage viruses provides limited immunity against Victoria lineage viruses. Here, we developed animal models to investigate the mechanisms behind asymmetric cross-protection between contemporary FLUBV lineages. Our results show that contemporary Victoria immunity provides robust cross-protection against the Yamagata lineage, whereas Yamagata immunity offers limited protection against the Victoria lineage. This differential cross-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-06-25T03:04:35.22Z","creation":"2025-06-25T03:04:35.22Z"},"accession":"S-EPMC11952091","cross_references":{"pubmed":["40153499"],"doi":["10.1126/sciadv.adu3344"]}}