{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Atalay AS"],"funding":["NICHD NIH HHS","NINDS NIH HHS"],"pubmed_abstract":["To enhance mechanistic understanding of effective connectivity in the human brain, we created a tool that links high-temporal resolution transcranial magnetic stimulation electroencephalography (TMS-EEG) with high-spatial resolution diffusion MRI. This tool, Surface to Tractography Real-time EEG Activation Mapping in 4 Dimensions (STREAM-4D), integrates electrophysiologic source estimation models from TMS-evoked potentials (TEPs) with structural connectivity models from diffusion MRI tractography. In a proof-of-principle application, we used STREAM-4D to analyze TMS-EEG and diffusion MRI tractography data in a neurotypical subject across three stimulation sites: premotor, parietal, and occipital cortex. STREAM-4D revealed extensive structural connections associated with the TMS-evoked sour"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.03.06.641642"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11952297"],"repository":["biostudies-literature"],"pubmed_title":["Visualizing Effective Connectivity in the Human Brain."],"pmcid":["PMC11952297"],"funding_grant_id":["DP2 HD101400","R01 NS138257"],"pubmed_authors":["Atalay AS","Edlow BL","Fecchio M"],"additional_accession":[]},"is_claimable":false,"name":"Visualizing Effective Connectivity in the Human Brain.","description":"To enhance mechanistic understanding of effective connectivity in the human brain, we created a tool that links high-temporal resolution transcranial magnetic stimulation electroencephalography (TMS-EEG) with high-spatial resolution diffusion MRI. This tool, Surface to Tractography Real-time EEG Activation Mapping in 4 Dimensions (STREAM-4D), integrates electrophysiologic source estimation models from TMS-evoked potentials (TEPs) with structural connectivity models from diffusion MRI tractography. In a proof-of-principle application, we used STREAM-4D to analyze TMS-EEG and diffusion MRI tractography data in a neurotypical subject across three stimulation sites: premotor, parietal, and occipital cortex. STREAM-4D revealed extensive structural connections associated with the TMS-evoked sour","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-07T03:09:18.492Z","creation":"2025-07-07T03:09:18.492Z"},"accession":"S-EPMC11952297","cross_references":{"pubmed":["40161749"],"doi":["10.1101/2025.03.06.641642"]}}