{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Obare LM"],"funding":["NCATS NIH HHS","NHLBI NIH HHS","National Institutes of Health","CZI Science Diversity","Burroughs Wellcome","Burroughs Wellcome Fund","Silicon Valley Community Foundation","Clinical Translational Science","The Myositis Association Pilot Award","UNCF","NIAMS NIH HHS","Vanderbilt Diabetes and Research Training Center","NIH HHS","Vanderbilt Ingram Cancer Center","National Center for Advancing Translational Sciences","Bristol-Myers Squibb","Chan Zuckerberg Initiative DAF","NIAID NIH HHS","Tennessee Center for AIDS Research","NIH","Small Research Pilot Subaward","DRTC Alzheimer’s Disease Pilot & Feasibility Program","NIDDK NIH HHS","DRTC Alzheimer's Disease Pilot & Feasibility Program","Vanderbilt Digestive Disease Research Center","Doris Duke","NCI NIH HHS","Vanderbilt Flow Cytometry Shared Resource"],"pagination":["516-531"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11952877"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["214(3)"],"pubmed_abstract":["Persistent systemic inflammation is associated with an elevated risk of cardiometabolic diseases. However, the characteristics of the innate and adaptive immune systems in individuals who develop these conditions remain poorly defined. Doublets, or cell-cell complexes, are routinely eliminated from flow cytometric and other immune phenotyping analyses, which limits our understanding of their relationship to disease states. Using well-characterized clinical cohorts, including participants with controlled human immunodeficiency virus (HIV) as a model for chronic inflammation and increased immune cell interactions, we show that circulating CD14+ monocytes complexed to CD3+ T cells are dynamic, biologically relevant, and increased in individuals with diabetes after adjusting for confounding fa"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance."],"pmcid":["PMC11952877"],"funding_grant_id":["UL1 TR002243","K08AR080808","1021868.01","KL2TR002245","R03HL155041","K23 HL159351","P30 AI110527","2022- 253529","P30 DK058404","#1022376","DK020593","R03 HL155041","P30 DK020593","K23 HL156759","P30 CA068485","R25 HL106365","CSDA 2021193","5UL1TR002243-03","R01HL144941","DK058404","K08 AR080808","1021480","R01 DK112262","5R25HL106365-12"],"pubmed_authors":["Priest S","Shao J","Neikirk K","Nochowicz C","Meenderink LM","Kalams SA","Ru Su Y","Absi T","Wanjalla CN","Bailin SS","Gianella S","Obare LM","Sheng Q","Stolze J","Harrison DG","Phillips EJ","Wilfong EM","Mashayekhi M","Koethe JR","Beasley HK","Gangula R","Hinton A","Simmons J","Kirabo A","Gabriel CL","Warren CM","Mallal SA","Oakes J","Temu T","Pakala S","Chopra A","Zhang X"],"additional_accession":[]},"is_claimable":false,"name":"CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance.","description":"Persistent systemic inflammation is associated with an elevated risk of cardiometabolic diseases. However, the characteristics of the innate and adaptive immune systems in individuals who develop these conditions remain poorly defined. Doublets, or cell-cell complexes, are routinely eliminated from flow cytometric and other immune phenotyping analyses, which limits our understanding of their relationship to disease states. Using well-characterized clinical cohorts, including participants with controlled human immunodeficiency virus (HIV) as a model for chronic inflammation and increased immune cell interactions, we show that circulating CD14+ monocytes complexed to CD3+ T cells are dynamic, biologically relevant, and increased in individuals with diabetes after adjusting for confounding fa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-08T18:31:28.481Z","creation":"2025-07-05T03:04:30.272Z"},"accession":"S-EPMC11952877","cross_references":{"pubmed":["40073149"],"doi":["10.1093/jimmun/vkae054"]}}