{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Knox JJ"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute"],"pagination":["317-324"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11952879"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["214(3)"],"pubmed_abstract":["The humoral immune system influences the development of atherosclerosis, but the contributions of specific memory B cell subsets and IgG isotypes are poorly understood. We assessed the relationship between atherosclerosis and age-associated B cells (ABCs), a T-bet-expressing memory B cell subset that is enriched for IgG2c production and implicated in humoral autoimmunity. We found increased numbers of splenic CD11c+ ABCs in 6-mo-old, chow-fed Apoe-/- mice versus C57BL/6 control mice, which were exacerbated by high-fat diet. Deletion of T-bet in the B lineage in high-fat diet-fed Apoe-/- mice reduced aortic lesion area, and this correlated with decreased splenic CD11c+ B cells and reduced serum oxidized low-density lipoprotein-specific IgG2c. Our findings suggest that T-bet-expressing B cel"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["T-bet-expressing B cells promote atherosclerosis in apolipoprotein E-deficient mice."],"pmcid":["PMC11952879"],"funding_grant_id":["T32 AI055428","T32 HL007954","T32 HL07954"],"pubmed_authors":["Rader DJ","Cancro MP","Cromley D","Pure E","Karolyi K","Knox JJ","Monslow J"],"additional_accession":[]},"is_claimable":false,"name":"T-bet-expressing B cells promote atherosclerosis in apolipoprotein E-deficient mice.","description":"The humoral immune system influences the development of atherosclerosis, but the contributions of specific memory B cell subsets and IgG isotypes are poorly understood. We assessed the relationship between atherosclerosis and age-associated B cells (ABCs), a T-bet-expressing memory B cell subset that is enriched for IgG2c production and implicated in humoral autoimmunity. We found increased numbers of splenic CD11c+ ABCs in 6-mo-old, chow-fed Apoe-/- mice versus C57BL/6 control mice, which were exacerbated by high-fat diet. Deletion of T-bet in the B lineage in high-fat diet-fed Apoe-/- mice reduced aortic lesion area, and this correlated with decreased splenic CD11c+ B cells and reduced serum oxidized low-density lipoprotein-specific IgG2c. Our findings suggest that T-bet-expressing B cel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-16T23:07:35.397Z","creation":"2026-07-12T03:10:41.366Z"},"accession":"S-EPMC11952879","cross_references":{"pubmed":["40073097"],"doi":["10.1093/jimmun/vkae027"]}}