{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi M"],"funding":["Wayne and Gladys Valley Foundation","NIA NIH HHS","Research Program on Genes, Environment, and Health, Kaiser Permanente Division of Research","Kaiser Permanente Northern California, Kaiser Permanente","National and Regional Community Benefit Programs, Kaiser Permanente","Genetic Epidemiology Research on Adult Health and Aging, Kaiser Permanente Division of Research","National Institutes of Health","National Institute on Aging","Ellison Medical Foundation","NIH HHS","Robert Wood Johnson Foundation"],"pagination":["e14627"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11953565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(3)"],"pubmed_abstract":["<h4>Introduction</h4>Mixed evidence on how statin use affects risk of Alzheimer's disease and related dementias (ADRD) may reflect heterogeneity across sociodemographic factors. Few studies have sufficient power to evaluate effect modifiers.<h4>Methods</h4>Kaiser Permanente Northern California (KPNC) members (n = 705,061; n = 202,937 with sociodemographic surveys) who initiated statins from 2001 to 2010 were matched on age and low-density lipoprotein cholesterol (LDL-C) with non-initiators and followed through 2020 for incident ADRD. Inverse probability-weighted Cox proportional hazards models were used to evaluate effect modification by age, gender, race/ethnicity, education, marital status, income, and immigrant generation.<h4>Results</h4>Statin initiation (vs non-initiation) was not ass"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Sociodemographic modifiers of effects of statin initiation on dementia incidence: An emulated trial design in a large health care member population with 10+ years of follow-up."],"pmcid":["PMC11953565"],"funding_grant_id":["RF1AG069259","RC2AG036607"],"pubmed_authors":["Schaefer CM","Risch N","Zimmerman SC","Whitmer RA","Swinnerton K","Gilsanz P","Ferguson EL","Glymour MM","Wang J","Choi M","Oni-Orisan A","Hoffmann TJ","Choudhary V","Meyers T","Jiang C","Krauss RM"],"additional_accession":[]},"is_claimable":false,"name":"Sociodemographic modifiers of effects of statin initiation on dementia incidence: An emulated trial design in a large health care member population with 10+ years of follow-up.","description":"<h4>Introduction</h4>Mixed evidence on how statin use affects risk of Alzheimer's disease and related dementias (ADRD) may reflect heterogeneity across sociodemographic factors. Few studies have sufficient power to evaluate effect modifiers.<h4>Methods</h4>Kaiser Permanente Northern California (KPNC) members (n = 705,061; n = 202,937 with sociodemographic surveys) who initiated statins from 2001 to 2010 were matched on age and low-density lipoprotein cholesterol (LDL-C) with non-initiators and followed through 2020 for incident ADRD. Inverse probability-weighted Cox proportional hazards models were used to evaluate effect modification by age, gender, race/ethnicity, education, marital status, income, and immigrant generation.<h4>Results</h4>Statin initiation (vs non-initiation) was not ass","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-13T03:04:48.203Z","creation":"2025-07-13T03:04:48.203Z"},"accession":"S-EPMC11953565","cross_references":{"pubmed":["40156267"],"doi":["10.1002/alz.14627"]}}