biostudies-literatureChoi MWayne and Gladys Valley FoundationNIA NIH HHSResearch Program on Genes, Environment, and Health, Kaiser Permanente Division of ResearchKaiser Permanente Northern California, Kaiser PermanenteNational and Regional Community Benefit Programs, Kaiser PermanenteGenetic Epidemiology Research on Adult Health and Aging, Kaiser Permanente Division of ResearchNational Institutes of HealthNational Institute on AgingEllison Medical FoundationNIH HHSRobert Wood Johnson Foundatione14627https://www.ebi.ac.uk/biostudies/studies/S-EPMC11953565biostudies-literatureUnknown21(3)<h4>Introduction</h4>Mixed evidence on how statin use affects risk of Alzheimer's disease and related dementias (ADRD) may reflect heterogeneity across sociodemographic factors. Few studies have sufficient power to evaluate effect modifiers.<h4>Methods</h4>Kaiser Permanente Northern California (KPNC) members (n = 705,061; n = 202,937 with sociodemographic surveys) who initiated statins from 2001 to 2010 were matched on age and low-density lipoprotein cholesterol (LDL-C) with non-initiators and followed through 2020 for incident ADRD. Inverse probability-weighted Cox proportional hazards models were used to evaluate effect modification by age, gender, race/ethnicity, education, marital status, income, and immigrant generation.<h4>Results</h4>Statin initiation (vs non-initiation) was not assAlzheimer's & dementia : the journal of the Alzheimer's AssociationSociodemographic modifiers of effects of statin initiation on dementia incidence: An emulated trial design in a large health care member population with 10+ years of follow-up.PMC11953565RF1AG069259RC2AG036607Schaefer CMRisch NZimmerman SCWhitmer RASwinnerton KGilsanz PFerguson ELGlymour MMWang JChoi MOni-Orisan AHoffmann TJChoudhary VMeyers TJiang CKrauss RMfalseSociodemographic modifiers of effects of statin initiation on dementia incidence: An emulated trial design in a large health care member population with 10+ years of follow-up.<h4>Introduction</h4>Mixed evidence on how statin use affects risk of Alzheimer's disease and related dementias (ADRD) may reflect heterogeneity across sociodemographic factors. Few studies have sufficient power to evaluate effect modifiers.<h4>Methods</h4>Kaiser Permanente Northern California (KPNC) members (n = 705,061; n = 202,937 with sociodemographic surveys) who initiated statins from 2001 to 2010 were matched on age and low-density lipoprotein cholesterol (LDL-C) with non-initiators and followed through 2020 for incident ADRD. Inverse probability-weighted Cox proportional hazards models were used to evaluate effect modification by age, gender, race/ethnicity, education, marital status, income, and immigrant generation.<h4>Results</h4>Statin initiation (vs non-initiation) was not ass2025-01-01T00:00:00Z2025 Mar2025-07-13T03:04:48.203Z2025-07-13T03:04:48.203ZS-EPMC119535654015626710.1002/alz.14627