biostudies-literatureUnknown26(1)Wang S<h4>Background</h4>Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate the effects of acute sleep deprivation (ASD) on brain function in individuals with migraine without aura (MWoA) via functional magnetic resonance imaging (fMRI).<h4>Methods</h4>Twenty three MWoA individuals and 23 healthy controls (HCs) were fairly included in this study. All participants underwent two MRI scans: one at baseline (prior to sleep deprivation) and another following 24 h of ASD. Images were obtained with blood-oxygen-level-dependent and T1-weighted sequences on a Siemens 7.0 T MRI scanner. We conducted analyses of changes in the low-frequency fluctuations (ALFF) values and funThe journal of headache and pain60https://www.ebi.ac.uk/biostudies/studies/S-EPMC11954264biostudies-literatureEffects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study.PMC11954264Zhai DMa LYu SDong ZDuan CLin XLou XZhang SSun YXie SLiu XLiu YWang RWang SBian XWang XfalseEffects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study.<h4>Background</h4>Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate the effects of acute sleep deprivation (ASD) on brain function in individuals with migraine without aura (MWoA) via functional magnetic resonance imaging (fMRI).<h4>Methods</h4>Twenty three MWoA individuals and 23 healthy controls (HCs) were fairly included in this study. All participants underwent two MRI scans: one at baseline (prior to sleep deprivation) and another following 24 h of ASD. Images were obtained with blood-oxygen-level-dependent and T1-weighted sequences on a Siemens 7.0 T MRI scanner. We conducted analyses of changes in the low-frequency fluctuations (ALFF) values and fun2025-01-01T00:00:00Z2025 Mar2026-06-02T12:01:06.463Z2026-04-18T03:10:54.393ZS-EPMC119542644015584310.1186/s10194-025-02004-4