biostudies-literatureUnknown19(1)El-Kafrawy DSThe pursuit of sustainability in analytical chemistry is a multifaceted, challenging and complex endeavor. This requires continuous and competitive attempts to achieve the sustainable development goals at every step of the analytical methodology by adhering to the principles of green, blue and white analytical chemistry. This also involves assessment of the degree of sustainability using the latest evaluation metrics until finally reaching the design of a trichromatic procedure. The herein illustrated work represents a comparative study between two newly developed normal-phase and reverse-phase HPTLC methods for the simultaneous quantitative determination of Remdesivir (RMD), Favipiravir (FAV) and Molnupiravir (MOL). For normal-phase HPTLC method, the employed mobile phase consisted of ethBMC chemistry83https://www.ebi.ac.uk/biostudies/studies/S-EPMC11954355biostudies-literatureComparative study of Normal-phase versus reversed-phase HPTLC methods for the concurrent quantification of three antiviral agents against COVID19: Remdesivir, favipiravir and Molnupiravir: trichromatic sustainability assessment.PMC11954355Abo-Gharam AHEl-Kafrawy DSfalseComparative study of Normal-phase versus reversed-phase HPTLC methods for the concurrent quantification of three antiviral agents against COVID19: Remdesivir, favipiravir and Molnupiravir: trichromatic sustainability assessment.The pursuit of sustainability in analytical chemistry is a multifaceted, challenging and complex endeavor. This requires continuous and competitive attempts to achieve the sustainable development goals at every step of the analytical methodology by adhering to the principles of green, blue and white analytical chemistry. This also involves assessment of the degree of sustainability using the latest evaluation metrics until finally reaching the design of a trichromatic procedure. The herein illustrated work represents a comparative study between two newly developed normal-phase and reverse-phase HPTLC methods for the simultaneous quantitative determination of Remdesivir (RMD), Favipiravir (FAV) and Molnupiravir (MOL). For normal-phase HPTLC method, the employed mobile phase consisted of eth2025-01-01T00:00:00Z2025 Mar2025-07-05T03:05:30.946Z2025-07-05T03:05:30.946ZS-EPMC119543554015594410.1186/s13065-025-01439-9