{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["69"],"submitter":["Chang KJ"],"pubmed_abstract":["<h4>Introduction</h4>The clinical presentations of dry eye disease (DED) and depression (DEP) often comanifest. However, the robustness and the mechanisms underlying this association were undetermined.<h4>Objectives</h4>To this end, we set up a three-segment study that employed multimodality results (meta-analysis, genome-wide association study [GWAS] and Mendelian randomization [MR]) to elucidate the association, common pathways and causality between DED and DEP.<h4>Methods</h4>A meta-analysis comprising 26 case-control studies was first conducted to confirm the DED-DEP association. Next, we performed a linkage disequilibrium (LD)-adjusted GWAS and targeted phenotype association study (PheWAS) in East Asian TW Biobank (TWB) and European UK Biobank (UKB) populations. Single-nucleotide poly"],"journal":["Journal of advanced research"],"pagination":["197-213"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11954816"],"repository":["biostudies-literature"],"pubmed_title":["Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization."],"pmcid":["PMC11954816"],"pubmed_authors":["Yu TH","Wu YR","Tsai HY","Li CY","Dai HJ","Chang YJ","Chen YC","Li CT","Wu HY","Chang KJ","Cheng CY","Hsu CC","Chen SJ","Hsu YT","Chiang PH","Weng PY","Yang YP","Chen YH","Hsieh AR","Chiou SH"],"additional_accession":[]},"is_claimable":false,"name":"Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization.","description":"<h4>Introduction</h4>The clinical presentations of dry eye disease (DED) and depression (DEP) often comanifest. However, the robustness and the mechanisms underlying this association were undetermined.<h4>Objectives</h4>To this end, we set up a three-segment study that employed multimodality results (meta-analysis, genome-wide association study [GWAS] and Mendelian randomization [MR]) to elucidate the association, common pathways and causality between DED and DEP.<h4>Methods</h4>A meta-analysis comprising 26 case-control studies was first conducted to confirm the DED-DEP association. Next, we performed a linkage disequilibrium (LD)-adjusted GWAS and targeted phenotype association study (PheWAS) in East Asian TW Biobank (TWB) and European UK Biobank (UKB) populations. Single-nucleotide poly","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-02T12:02:02.035Z","creation":"2026-04-18T03:11:02.948Z"},"accession":"S-EPMC11954816","cross_references":{"pubmed":["38548265"],"doi":["10.1016/j.jare.2024.03.015"]}}