{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["69"],"submitter":["Li S"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["<h4>Introduction</h4>Inflammatory bowel disease (IBD) is a global disease with limited therapy. It is reported that sedanolide exerts anti-oxidative and anti-inflammatory effects as a natural phthalide, but its effects on IBD remain unclear.<h4>Objectives</h4>In this study, we investigated the impacts of sedanolide on dextran sodium sulfate (DSS)-induced colitis in mice.<h4>Methods</h4>The mice were administered sedanolide or vehicle followed by DSS administration, after which colitis symptoms, inflammation levels, and intestinal barrier function were evaluated. Transcriptome analysis, 16S rRNA sequencing, and targeted metabolomics analysis of bile acids and lipids were performed.<h4>Results</h4>Sedanolide protected mice from DSS-induced colitis, suppressed the inflammation, restored the w"],"journal":["Journal of advanced research"],"pagination":["413-426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11954817"],"repository":["biostudies-literature"],"pubmed_title":["Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice."],"pmcid":["PMC11954817"],"pubmed_authors":["Xia H","Shen J","Xia J","Li S","Jiang S","Chen H","Han S","Li L","Wang K","Wu Y","Zhuge A"],"additional_accession":[]},"is_claimable":false,"name":"Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice.","description":"<h4>Introduction</h4>Inflammatory bowel disease (IBD) is a global disease with limited therapy. It is reported that sedanolide exerts anti-oxidative and anti-inflammatory effects as a natural phthalide, but its effects on IBD remain unclear.<h4>Objectives</h4>In this study, we investigated the impacts of sedanolide on dextran sodium sulfate (DSS)-induced colitis in mice.<h4>Methods</h4>The mice were administered sedanolide or vehicle followed by DSS administration, after which colitis symptoms, inflammation levels, and intestinal barrier function were evaluated. Transcriptome analysis, 16S rRNA sequencing, and targeted metabolomics analysis of bile acids and lipids were performed.<h4>Results</h4>Sedanolide protected mice from DSS-induced colitis, suppressed the inflammation, restored the w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-07-05T03:04:17.956Z","creation":"2025-07-05T03:04:17.956Z"},"accession":"S-EPMC11954817","cross_references":{"pubmed":["38582300"],"doi":["10.1016/j.jare.2024.03.026"]}}