{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["You H"],"funding":["National Natural Science Foundation of China","Changzhou Sci & Tech Program","National Natural Science Foundation of China (National Science Foundation of China)","National Science Foundation of China | Key Programme"],"pagination":["356-370"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11955531"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(4)"],"pubmed_abstract":["T-cell receptor (TCR) γδ-expressing cells are conserved lymphocytes of innate immunity involved in first-line defense and immune surveillance. TCRγδ recognizes protein/nonprotein ligands without the help of the major histocompatibility complex (MHC), especially via direct binding to protein ligands, which is dependent primarily on the δ chain complementary determining region 3 (CDR3δ). However, the mechanism of protein‒antigen recognition by human γδ TCRs remains poorly defined. We hypothesize that γδ TCRs recognize self-proteins expressed ectopically on the cell membrane that are derived from intracellular components under stress. Here, we mapped 16 intercellular self-proteins among 21,000 proteins with a huProteinChip as putative ligands for Vδ1/Vδ2 TCRs, 13 for Vδ1 TCRs and 3 for Vδ2 TC"],"journal":["Cellular & molecular immunology"],"pubmed_title":["γδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition."],"pmcid":["PMC11955531"],"funding_grant_id":["32300745","32270915","82103319","U20A20374","82071791"],"pubmed_authors":["Hu Y","Zhang J","Cai M","Chen M","Chen H","Dong Q","Pang Y","Dong P","Zhao Y","Wang S","He W","Zhang X","Teng D","Liu C","Han J","You H","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"γδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition.","description":"T-cell receptor (TCR) γδ-expressing cells are conserved lymphocytes of innate immunity involved in first-line defense and immune surveillance. TCRγδ recognizes protein/nonprotein ligands without the help of the major histocompatibility complex (MHC), especially via direct binding to protein ligands, which is dependent primarily on the δ chain complementary determining region 3 (CDR3δ). However, the mechanism of protein‒antigen recognition by human γδ TCRs remains poorly defined. We hypothesize that γδ TCRs recognize self-proteins expressed ectopically on the cell membrane that are derived from intracellular components under stress. Here, we mapped 16 intercellular self-proteins among 21,000 proteins with a huProteinChip as putative ligands for Vδ1/Vδ2 TCRs, 13 for Vδ1 TCRs and 3 for Vδ2 TC","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-02T18:10:16.841Z","creation":"2025-07-11T03:04:00.556Z"},"accession":"S-EPMC11955531","cross_references":{"pubmed":["39939816"],"doi":["10.1038/s41423-025-01258-x"]}}