{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guangbin P"],"funding":["National Natural Science Foundation of China: Study on the Protective Mechanism of Moxibustion on Intestinal Mucosal Barrier in Ulcerative Colitis based on GABAergic System","State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project","Shanghai Sailing Program: to Study the Protective Effect of Moxibustion on Intestinal Mucosal Barrier in Crohn's Disease Based on Histone H3 Acetylation Modification","National Natural Science Foundation of China: Study for the Mechanism of Moxibustion in Ulcerative Colitis based on the α7 Nicotinic Acetylcholine Receptor Mediated Cholinergic Anti-inflammatory Pathway","National Natural Science Foundation of China: Moxibustion Regulates P300-mediated Histone H3K27 Acetylation Modification in the Treatment of Crohn's Disease","National Natural Science Foundation of China: Study of the Central Nervous System Regulatory Mechanism of Moxibustion Repair of Ulcerative Colitis Gut Vascular Barrier Based on Ubiquitin Specific Peptidase 14 Deubiquitination"],"pagination":["368-375"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11955752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(2)"],"pubmed_abstract":["Objective
To investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system (NNCS) in rats with ulcerative colitis (UC).Methods
UC rat model was established by administering 4% dextran sulfate sodium. After 7 d, mild moxibustion, α7 nicotinic acetylcholine receptors (α7nAchRs) antagonist (α-bungarotoxin, α-BGT), vesicular acetylcholine transport inhibitor (vesamicol hydrochloride, VH) and organic cation transporters inhibitor (quinine, Qu) treatments were performed once daily for 7 d. Haematoxylin and eosin staining was used for morphological evaluation of colon tissues. Enzyme-linked immunosorbent assay (ELISA) was used to measure the protein expressions of interleukin-1β (IL-1β) and choline acetyltransferase (ChAT) in colon tissue. Reverse"],"journal":["Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan"],"pubmed_title":["Regulation of mild moxibustion on non-neuronal cholinergic system in ulcerative colitis rats."],"pmcid":["PMC11955752"],"funding_grant_id":["82105012","22YF1444100","82274641","82205293","82205262","zyyzdxk-2023068"],"pubmed_authors":["Qin QI","Zhe MA","Linshan Z","Guangbin P","Lu Z","Shiyu Z","Yaying L","Luyi WU","Yan H","Han LI","Huangan WU"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of mild moxibustion on non-neuronal cholinergic system in ulcerative colitis rats.","description":"Objective
To investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system (NNCS) in rats with ulcerative colitis (UC).Methods
UC rat model was established by administering 4% dextran sulfate sodium. After 7 d, mild moxibustion, α7 nicotinic acetylcholine receptors (α7nAchRs) antagonist (α-bungarotoxin, α-BGT), vesicular acetylcholine transport inhibitor (vesamicol hydrochloride, VH) and organic cation transporters inhibitor (quinine, Qu) treatments were performed once daily for 7 d. Haematoxylin and eosin staining was used for morphological evaluation of colon tissues. Enzyme-linked immunosorbent assay (ELISA) was used to measure the protein expressions of interleukin-1β (IL-1β) and choline acetyltransferase (ChAT) in colon tissue. Reverse","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-07-03T03:06:43.91Z","creation":"2025-07-03T03:06:43.91Z"},"accession":"S-EPMC11955752","cross_references":{"pubmed":["40151123"],"doi":["10.19852/j.cnki.jtcm.2025.02.013"]}}