biostudies-literatureYue LIScience and Technology Research Project of Education Department of Liaoning Province: the Mechanism of Regulating Lipophagy and Affecting Cholesterol Efflux in Human Promyelocytic Leukemia Cell Line Macrophages by Huayu Qutan Recipe based on the Theory of "Laoxia Shengtan"Youth Project of Basic Scientific Research Project of Education Department of Liaoning Province: Mechanism of Mitochondrial Autophagy and Apoptosis in L02 Hepatocytes Regulated by miR-7043-3p based on the Theory of "Spleen Qi Dispersing Essence" of Huayu Qutan Recipe291-302https://www.ebi.ac.uk/biostudies/studies/S-EPMC11955768biostudies-literatureUnknown45(2)<h4>Objective</h4>To investigate the effects of Huayu Qutan recipe (, HYQT) on the atherosclerosis (AS) model of ApoE-/- mice with a high-fat diet and to illustrate the underlying mechanisms from modern patho-physiological conceptualizations.<h4>Methods</h4>High performance liquid chromatography of quadrupole time of flight-tandem mass spectrometry (HPLC-Q-TOF-MS/MS) analysis was used to identify the active compounds in the recipe. The mice were randomly allocated into 7 groups: control (CTRL) group, normal diet (ND) group, high-fat diet (HFD) group, HYQT groups (low dose, medium dose, and high dose), and simvastatin (SIM) group. Deferent doses of HYQT were gavaged twice a day, and then the protective effect of HYQT on plaque formation in ApoE-/- mice with a high-fat diet was verified <i>vJournal of traditional Chinese medicine = Chung i tsa chih ying wen panMechanism of Huayu Qutan recipe anti-atherosclerosis mediates lipophagymammalian target of rapamycin complex 1/ transcription factor EB signaling pathway in ApoE-/-mice.PMC11955768L202048LJKQZ2021064Lianqun JJiajia YUYue LILihong GLinlin PDongyu MXiaoyu GXize WUJiaxiang PGuanlin YMeijia CDongdong YUMinghua NfalseMechanism of Huayu Qutan recipe anti-atherosclerosis mediates lipophagymammalian target of rapamycin complex 1/ transcription factor EB signaling pathway in ApoE-/-mice.<h4>Objective</h4>To investigate the effects of Huayu Qutan recipe (, HYQT) on the atherosclerosis (AS) model of ApoE-/- mice with a high-fat diet and to illustrate the underlying mechanisms from modern patho-physiological conceptualizations.<h4>Methods</h4>High performance liquid chromatography of quadrupole time of flight-tandem mass spectrometry (HPLC-Q-TOF-MS/MS) analysis was used to identify the active compounds in the recipe. The mice were randomly allocated into 7 groups: control (CTRL) group, normal diet (ND) group, high-fat diet (HFD) group, HYQT groups (low dose, medium dose, and high dose), and simvastatin (SIM) group. Deferent doses of HYQT were gavaged twice a day, and then the protective effect of HYQT on plaque formation in ApoE-/- mice with a high-fat diet was verified <i>v2025-01-01T00:00:00Z2025 Apr2025-07-03T03:06:59.794Z2025-07-03T03:06:59.794ZS-EPMC119557684015111610.19852/j.cnki.jtcm.2025.02.016